| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGF | ERBB2 | ENSAMEP00000015773 | ENSAMEP00000010504 | Epidermal growth factor. | Receptor protein-tyrosine kinase. | 0.987 |
| EGF | IGF1 | ENSAMEP00000015773 | ENSAMEP00000006724 | Epidermal growth factor. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.961 |
| EGF | IGF1R | ENSAMEP00000015773 | ENSAMEP00000006007 | Epidermal growth factor. | Tyrosine-protein kinase receptor. | 0.909 |
| EGF | INS-IGF2 | ENSAMEP00000015773 | ENSAMEP00000002279 | Epidermal growth factor. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.983 |
| EGF | INSR | ENSAMEP00000015773 | ENSAMEP00000008683 | Epidermal growth factor. | Tyrosine-protein kinase receptor. | 0.939 |
| EGF | INSRR | ENSAMEP00000015773 | ENSAMEP00000015514 | Epidermal growth factor. | Uncharacterized protein. | 0.775 |
| EGF | PDGFRA | ENSAMEP00000015773 | ENSAMEP00000019410 | Epidermal growth factor. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.933 |
| ERBB2 | EGF | ENSAMEP00000010504 | ENSAMEP00000015773 | Receptor protein-tyrosine kinase. | Epidermal growth factor. | 0.987 |
| ERBB2 | IGF1 | ENSAMEP00000010504 | ENSAMEP00000006724 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.925 |
| ERBB2 | IGF1R | ENSAMEP00000010504 | ENSAMEP00000006007 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.927 |
| ERBB2 | INS-IGF2 | ENSAMEP00000010504 | ENSAMEP00000002279 | Receptor protein-tyrosine kinase. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.952 |
| ERBB2 | INSR | ENSAMEP00000010504 | ENSAMEP00000008683 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.941 |
| G1M8X5_AILME | IGF1 | ENSAMEP00000015795 | ENSAMEP00000006724 | PH domain-containing protein. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.543 |
| G1M8X5_AILME | IGF1R | ENSAMEP00000015795 | ENSAMEP00000006007 | PH domain-containing protein. | Tyrosine-protein kinase receptor. | 0.916 |
| G1M8X5_AILME | INS-IGF2 | ENSAMEP00000015795 | ENSAMEP00000002279 | PH domain-containing protein. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.959 |
| G1M8X5_AILME | INSR | ENSAMEP00000015795 | ENSAMEP00000008683 | PH domain-containing protein. | Tyrosine-protein kinase receptor. | 0.975 |
| G1M8X5_AILME | INSRR | ENSAMEP00000015795 | ENSAMEP00000015514 | PH domain-containing protein. | Uncharacterized protein. | 0.638 |
| GHRL | IGF1 | ENSAMEP00000016898 | ENSAMEP00000006724 | Uncharacterized protein. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.842 |
| GHRL | INS-IGF2 | ENSAMEP00000016898 | ENSAMEP00000002279 | Uncharacterized protein. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.953 |
| IDE | INS-IGF2 | ENSAMEP00000014952 | ENSAMEP00000002279 | Insulin degrading enzyme; Belongs to the peptidase M16 family. | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.983 |