USP44 protein (Ailuropoda melanoleuca) - STRING interaction network

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USP44

Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...] (711 aa)

Predicted Functional Partners:

CDC20

0.835

CDC20B

0.835

NCOR1

0.825

NCOR2

0.825

USP49

0.807

EZH2

0.806

KRR1

0.800

CETN2

0.753

CETN1

0.750

TADA3

0.675

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC20	CDC20B	ENSAMEP00000001735	ENSAMEP00000009928	Cell division cycle 20.	Cell division cycle 20B.	0.564
CDC20	USP44	ENSAMEP00000001735	ENSAMEP00000002292	Cell division cycle 20.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.835
CDC20	USP49	ENSAMEP00000001735	ENSAMEP00000013756	Cell division cycle 20.	Ubiquitinyl hydrolase 1.	0.664
CDC20B	CDC20	ENSAMEP00000009928	ENSAMEP00000001735	Cell division cycle 20B.	Cell division cycle 20.	0.564
CDC20B	USP44	ENSAMEP00000009928	ENSAMEP00000002292	Cell division cycle 20B.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.835
CDC20B	USP49	ENSAMEP00000009928	ENSAMEP00000013756	Cell division cycle 20B.	Ubiquitinyl hydrolase 1.	0.664
CETN1	USP44	ENSAMEP00000020897	ENSAMEP00000002292	Centrin 1.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.750
CETN1	USP49	ENSAMEP00000020897	ENSAMEP00000013756	Centrin 1.	Ubiquitinyl hydrolase 1.	0.474
CETN2	USP44	ENSAMEP00000000382	ENSAMEP00000002292	Centrin 2.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.753
CETN2	USP49	ENSAMEP00000000382	ENSAMEP00000013756	Centrin 2.	Ubiquitinyl hydrolase 1.	0.474
EZH2	USP44	ENSAMEP00000003001	ENSAMEP00000002292	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.806
KRR1	USP44	ENSAMEP00000006793	ENSAMEP00000002292	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.800
KRR1	USP49	ENSAMEP00000006793	ENSAMEP00000013756	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	Ubiquitinyl hydrolase 1.	0.493
NCOR1	NCOR2	ENSAMEP00000004955	ENSAMEP00000016359	Nuclear receptor corepressor 1.	Nuclear receptor corepressor 2.	0.970
NCOR1	TADA3	ENSAMEP00000004955	ENSAMEP00000017166	Nuclear receptor corepressor 1.	Transcriptional adaptor 3.	0.778
NCOR1	USP44	ENSAMEP00000004955	ENSAMEP00000002292	Nuclear receptor corepressor 1.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.825
NCOR1	USP49	ENSAMEP00000004955	ENSAMEP00000013756	Nuclear receptor corepressor 1.	Ubiquitinyl hydrolase 1.	0.423
NCOR2	NCOR1	ENSAMEP00000016359	ENSAMEP00000004955	Nuclear receptor corepressor 2.	Nuclear receptor corepressor 1.	0.970
NCOR2	TADA3	ENSAMEP00000016359	ENSAMEP00000017166	Nuclear receptor corepressor 2.	Transcriptional adaptor 3.	0.778
NCOR2	USP44	ENSAMEP00000016359	ENSAMEP00000002292	Nuclear receptor corepressor 2.	Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...]	0.825

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