PIAS4 protein (Ailuropoda melanoleuca) - STRING interaction network

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Predicted Interactions

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Score

PIAS4

Protein inhibitor of activated STAT 4. (518 aa)

Predicted Functional Partners:

G1MPB9_AILME

0.820

UBE2I

0.751

G1MIS9_AILME

0.751

RNF168

0.743

ATM

0.724

UBE2N

0.714

SUMO3

0.713

SUMO2

0.713

G1ML86_AILME

0.713

IKBKG

0.692

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	G1MIS9_AILME	ENSAMEP00000017701	ENSAMEP00000019264	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.484
ATM	G1MPB9_AILME	ENSAMEP00000017701	ENSAMEP00000021221	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Small ubiquitin-related modifier.	0.677
ATM	IKBKG	ENSAMEP00000017701	ENSAMEP00000000435	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.687
ATM	PIAS4	ENSAMEP00000017701	ENSAMEP00000002383	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein inhibitor of activated STAT 4.	0.724
ATM	RNF168	ENSAMEP00000017701	ENSAMEP00000003985	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ring finger protein 168.	0.809
ATM	UBE2I	ENSAMEP00000017701	ENSAMEP00000008152	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.484
ATM	UBE2N	ENSAMEP00000017701	ENSAMEP00000010336	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.632
G1MIS9_AILME	ATM	ENSAMEP00000019264	ENSAMEP00000017701	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.484
G1MIS9_AILME	G1ML86_AILME	ENSAMEP00000019264	ENSAMEP00000020121	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.874
G1MIS9_AILME	G1MPB9_AILME	ENSAMEP00000019264	ENSAMEP00000021221	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.942
G1MIS9_AILME	PIAS4	ENSAMEP00000019264	ENSAMEP00000002383	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT 4.	0.751
G1MIS9_AILME	RNF168	ENSAMEP00000019264	ENSAMEP00000003985	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ring finger protein 168.	0.428
G1MIS9_AILME	SUMO2	ENSAMEP00000019264	ENSAMEP00000009654	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.875
G1MIS9_AILME	SUMO3	ENSAMEP00000019264	ENSAMEP00000002172	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.875
G1MIS9_AILME	UBE2N	ENSAMEP00000019264	ENSAMEP00000010336	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.489
G1ML86_AILME	G1MIS9_AILME	ENSAMEP00000020121	ENSAMEP00000019264	Small ubiquitin-related modifier.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.874
G1ML86_AILME	G1MPB9_AILME	ENSAMEP00000020121	ENSAMEP00000021221	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.699
G1ML86_AILME	PIAS4	ENSAMEP00000020121	ENSAMEP00000002383	Small ubiquitin-related modifier.	Protein inhibitor of activated STAT 4.	0.713
G1ML86_AILME	RNF168	ENSAMEP00000020121	ENSAMEP00000003985	Small ubiquitin-related modifier.	Ring finger protein 168.	0.595
G1ML86_AILME	UBE2I	ENSAMEP00000020121	ENSAMEP00000008152	Small ubiquitin-related modifier.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.874