STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (701 aa)    
Predicted Functional Partners:
HCN3
Hyperpolarization activated cyclic nucleotide gated potassium channel 3.
  
 
0.941
HCN1
Hyperpolarization activated cyclic nucleotide gated potassium channel 1.
  
  
 
0.901
TBX5
T-box transcription factor 5.
   
  
 0.555
KCNJ2
Potassium voltage-gated channel subfamily J member 2.
      
 0.553
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
     
 0.477
SYT2
Synaptotagmin 2.
    
 
 0.465
SYT1
Synaptotagmin 1.
    
 
 0.465
CAV3
Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.
    
 
 0.462
ATP2B3
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
   
  
 0.455
KCNA5
Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.
     
 0.455
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.