ABCA7 protein (Ailuropoda melanoleuca) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ABCA7

ABC transporter domain-containing protein. (807 aa)

Predicted Functional Partners:

PSEN2

0.728

BIN1

0.689

APOE

0.685

PSEN1

0.629

PTK2B

0.625

CLU

0.618

SORL1

0.617

SLC24A4

0.589

TREM2

0.558

TREML1

0.558

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA7	APOE	ENSAMEP00000003142	ENSAMEP00000013408	ABC transporter domain-containing protein.	Apolipoprotein E.	0.685
ABCA7	BIN1	ENSAMEP00000003142	ENSAMEP00000017898	ABC transporter domain-containing protein.	Bridging integrator 1.	0.689
ABCA7	CLU	ENSAMEP00000003142	ENSAMEP00000000156	ABC transporter domain-containing protein.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.618
ABCA7	PSEN1	ENSAMEP00000003142	ENSAMEP00000019242	ABC transporter domain-containing protein.	Presenilin 1.	0.629
ABCA7	PSEN2	ENSAMEP00000003142	ENSAMEP00000009556	ABC transporter domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.728
ABCA7	PTK2B	ENSAMEP00000003142	ENSAMEP00000000220	ABC transporter domain-containing protein.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.625
ABCA7	SLC24A4	ENSAMEP00000003142	ENSAMEP00000014509	ABC transporter domain-containing protein.	Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.589
ABCA7	SORL1	ENSAMEP00000003142	ENSAMEP00000008783	ABC transporter domain-containing protein.	Sortilin related receptor 1.	0.617
ABCA7	TREM2	ENSAMEP00000003142	ENSAMEP00000004625	ABC transporter domain-containing protein.	Triggering receptor expressed on myeloid cells 2.	0.558
ABCA7	TREML1	ENSAMEP00000003142	ENSAMEP00000004635	ABC transporter domain-containing protein.	Triggering receptor expressed on myeloid cells like 1.	0.558
APOE	ABCA7	ENSAMEP00000013408	ENSAMEP00000003142	Apolipoprotein E.	ABC transporter domain-containing protein.	0.685
APOE	CLU	ENSAMEP00000013408	ENSAMEP00000000156	Apolipoprotein E.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.759
APOE	PSEN1	ENSAMEP00000013408	ENSAMEP00000019242	Apolipoprotein E.	Presenilin 1.	0.627
APOE	PSEN2	ENSAMEP00000013408	ENSAMEP00000009556	Apolipoprotein E.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.619
APOE	SORL1	ENSAMEP00000013408	ENSAMEP00000008783	Apolipoprotein E.	Sortilin related receptor 1.	0.633
APOE	TREM2	ENSAMEP00000013408	ENSAMEP00000004625	Apolipoprotein E.	Triggering receptor expressed on myeloid cells 2.	0.753
APOE	TREML1	ENSAMEP00000013408	ENSAMEP00000004635	Apolipoprotein E.	Triggering receptor expressed on myeloid cells like 1.	0.753
BIN1	ABCA7	ENSAMEP00000017898	ENSAMEP00000003142	Bridging integrator 1.	ABC transporter domain-containing protein.	0.689
BIN1	SORL1	ENSAMEP00000017898	ENSAMEP00000008783	Bridging integrator 1.	Sortilin related receptor 1.	0.491
CLU	ABCA7	ENSAMEP00000000156	ENSAMEP00000003142	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	ABC transporter domain-containing protein.	0.618