STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCNL1Cyclin L1; Belongs to the cyclin family. (528 aa)    
Predicted Functional Partners:
CDK9
Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.
      
 0.744
ZNF276
Zinc finger protein 276.
   
  
 0.738
CDK12
Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...]
      
 0.683
CDK20
Cyclin dependent kinase 20; Belongs to the protein kinase superfamily.
      
 0.662
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.637
CDK10
Cyclin dependent kinase 10; Belongs to the protein kinase superfamily.
   
 
 0.627
CCNH
Cyclin H; Belongs to the cyclin family.
      
 0.612
NELFE
Negative elongation factor complex member E.
      
 0.609
MEPCE
Methylphosphate capping enzyme.
      
 0.558
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
  
 0.551
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.