RAD17 protein (Ailuropoda melanoleuca) - STRING interaction network

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RAD17

RAD17 checkpoint clamp loader component. (682 aa)

Predicted Functional Partners:

RFC2

0.997

RFC4

0.996

RFC3

0.996

RAD9A

0.991

RFC5

0.991

RAD1

0.987

ATR

0.965

ATM

0.949

TOPBP1

0.943

ATAD5

0.931

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ATM	ENSAMEP00000005855	ENSAMEP00000017701	ATPase family AAA domain containing 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.565
ATAD5	ATR	ENSAMEP00000005855	ENSAMEP00000013271	ATPase family AAA domain containing 5.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.682
ATAD5	RAD1	ENSAMEP00000005855	ENSAMEP00000003490	ATPase family AAA domain containing 5.	RAD1 checkpoint DNA exonuclease.	0.803
ATAD5	RAD17	ENSAMEP00000005855	ENSAMEP00000003427	ATPase family AAA domain containing 5.	RAD17 checkpoint clamp loader component.	0.931
ATAD5	RAD9A	ENSAMEP00000005855	ENSAMEP00000000782	ATPase family AAA domain containing 5.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.803
ATAD5	RFC2	ENSAMEP00000005855	ENSAMEP00000016246	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.959
ATAD5	RFC3	ENSAMEP00000005855	ENSAMEP00000009724	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.959
ATAD5	RFC4	ENSAMEP00000005855	ENSAMEP00000000997	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.986
ATAD5	RFC5	ENSAMEP00000005855	ENSAMEP00000017097	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.986
ATAD5	TOPBP1	ENSAMEP00000005855	ENSAMEP00000000427	ATPase family AAA domain containing 5.	DNA topoisomerase II binding protein 1.	0.437
ATM	ATAD5	ENSAMEP00000017701	ENSAMEP00000005855	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain containing 5.	0.565
ATM	ATR	ENSAMEP00000017701	ENSAMEP00000013271	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.991
ATM	RAD1	ENSAMEP00000017701	ENSAMEP00000003490	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD1 checkpoint DNA exonuclease.	0.934
ATM	RAD17	ENSAMEP00000017701	ENSAMEP00000003427	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD17 checkpoint clamp loader component.	0.949
ATM	RAD9A	ENSAMEP00000017701	ENSAMEP00000000782	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.907
ATM	RFC2	ENSAMEP00000017701	ENSAMEP00000016246	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 2.	0.837
ATM	RFC3	ENSAMEP00000017701	ENSAMEP00000009724	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 3.	0.810
ATM	RFC4	ENSAMEP00000017701	ENSAMEP00000000997	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 4.	0.852
ATM	RFC5	ENSAMEP00000017701	ENSAMEP00000017097	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 5.	0.708
ATM	TOPBP1	ENSAMEP00000017701	ENSAMEP00000000427	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA topoisomerase II binding protein 1.	0.954