STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)    
Predicted Functional Partners:
HIPK2
Homeodomain interacting protein kinase 2.
   
  0.989
HIPK3
Homeodomain interacting protein kinase 3.
   
  0.953
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.952
RASSF5
Ras association domain family member 5.
    
 0.923
HIPK4
Homeodomain interacting protein kinase 4.
     
 0.714
FHL3
Four and a half LIM domains 3.
    
 
 0.667
ZNF596
Zinc finger protein 596.
    
 
 0.646
PML
Promyelocytic leukemia.
    
 
 0.622
DAXX
Death domain associated protein.
    
 
 0.616
TMCO5A
Transmembrane and coiled-coil domains 5A.
      
 0.604
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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