DCLRE1B protein (Ailuropoda melanoleuca) - STRING interaction network

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DCLRE1B

5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] (530 aa)

Predicted Functional Partners:

CPSF1

0.770

XRCC5

0.748

SYMPK

0.745

XRCC6

0.736

WDR82

0.732

FANCM

0.731

INTS4

0.722

FIP1L1

0.717

G1ME18_AILME

0.702

ZNF524

0.694

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPSF1	DCLRE1B	ENSAMEP00000005940	ENSAMEP00000003441	Cleavage and polyadenylation specific factor 1.	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	0.770
CPSF1	FIP1L1	ENSAMEP00000005940	ENSAMEP00000008525	Cleavage and polyadenylation specific factor 1.	Factor interacting with PAPOLA and CPSF1.	0.990
CPSF1	SYMPK	ENSAMEP00000005940	ENSAMEP00000000783	Cleavage and polyadenylation specific factor 1.	Symplekin.	0.997
CPSF1	WDR82	ENSAMEP00000005940	ENSAMEP00000009504	Cleavage and polyadenylation specific factor 1.	WD repeat domain 82.	0.985
DCLRE1B	CPSF1	ENSAMEP00000003441	ENSAMEP00000005940	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Cleavage and polyadenylation specific factor 1.	0.770
DCLRE1B	FANCM	ENSAMEP00000003441	ENSAMEP00000002260	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	FA complementation group M.	0.731
DCLRE1B	FIP1L1	ENSAMEP00000003441	ENSAMEP00000008525	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Factor interacting with PAPOLA and CPSF1.	0.717
DCLRE1B	G1ME18_AILME	ENSAMEP00000003441	ENSAMEP00000017596	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Uncharacterized protein.	0.702
DCLRE1B	INTS4	ENSAMEP00000003441	ENSAMEP00000002282	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Integrator complex subunit 4.	0.722
DCLRE1B	SYMPK	ENSAMEP00000003441	ENSAMEP00000000783	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Symplekin.	0.745
DCLRE1B	WDR82	ENSAMEP00000003441	ENSAMEP00000009504	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	WD repeat domain 82.	0.732
DCLRE1B	XRCC5	ENSAMEP00000003441	ENSAMEP00000003663	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	X-ray repair cross complementing 5.	0.748
DCLRE1B	XRCC6	ENSAMEP00000003441	ENSAMEP00000016448	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	X-ray repair cross complementing 6.	0.736
DCLRE1B	ZNF524	ENSAMEP00000003441	ENSAMEP00000019959	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	Zinc finger protein 524.	0.694
FANCM	DCLRE1B	ENSAMEP00000002260	ENSAMEP00000003441	FA complementation group M.	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	0.731
FANCM	XRCC5	ENSAMEP00000002260	ENSAMEP00000003663	FA complementation group M.	X-ray repair cross complementing 5.	0.491
FANCM	XRCC6	ENSAMEP00000002260	ENSAMEP00000016448	FA complementation group M.	X-ray repair cross complementing 6.	0.534
FIP1L1	CPSF1	ENSAMEP00000008525	ENSAMEP00000005940	Factor interacting with PAPOLA and CPSF1.	Cleavage and polyadenylation specific factor 1.	0.990
FIP1L1	DCLRE1B	ENSAMEP00000008525	ENSAMEP00000003441	Factor interacting with PAPOLA and CPSF1.	5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...]	0.717
FIP1L1	SYMPK	ENSAMEP00000008525	ENSAMEP00000000783	Factor interacting with PAPOLA and CPSF1.	Symplekin.	0.996

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