IL6 protein (Ailuropoda melanoleuca) - STRING interaction network

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Score

IL6

Uncharacterized protein. (211 aa)

Predicted Functional Partners:

IL6R

0.999

G1LQS2_AILME

0.989

IFNG

0.984

RELA

0.980

OSM

0.976

IL11

0.975

IL4

0.975

JUN

0.971

IL13

0.971

IL6ST

0.963

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1LQS2_AILME	IFNG	ENSAMEP00000009406	ENSAMEP00000009180	Death domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.696
G1LQS2_AILME	IL4	ENSAMEP00000009406	ENSAMEP00000018721	Death domain-containing protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.599
G1LQS2_AILME	IL6	ENSAMEP00000009406	ENSAMEP00000003506	Death domain-containing protein.	Uncharacterized protein.	0.989
G1LQS2_AILME	JUN	ENSAMEP00000009406	ENSAMEP00000000287	Death domain-containing protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.740
G1LQS2_AILME	RELA	ENSAMEP00000009406	ENSAMEP00000018355	Death domain-containing protein.	RELA proto-oncogene, NF-kB subunit.	0.998
IFNG	G1LQS2_AILME	ENSAMEP00000009180	ENSAMEP00000009406	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Death domain-containing protein.	0.696
IFNG	IL11	ENSAMEP00000009180	ENSAMEP00000003958	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interleukin 11.	0.577
IFNG	IL13	ENSAMEP00000009180	ENSAMEP00000018719	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interleukin 13.	0.950
IFNG	IL4	ENSAMEP00000009180	ENSAMEP00000018721	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.977
IFNG	IL6	ENSAMEP00000009180	ENSAMEP00000003506	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Uncharacterized protein.	0.984
IFNG	IL6R	ENSAMEP00000009180	ENSAMEP00000012289	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interleukin 6 receptor.	0.903
IFNG	IL6ST	ENSAMEP00000009180	ENSAMEP00000003839	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Interleukin 6 signal transducer.	0.851
IFNG	JUN	ENSAMEP00000009180	ENSAMEP00000000287	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.643
IL11	IFNG	ENSAMEP00000003958	ENSAMEP00000009180	Interleukin 11.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.577
IL11	IL13	ENSAMEP00000003958	ENSAMEP00000018719	Interleukin 11.	Interleukin 13.	0.948
IL11	IL4	ENSAMEP00000003958	ENSAMEP00000018721	Interleukin 11.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.449
IL11	IL6	ENSAMEP00000003958	ENSAMEP00000003506	Interleukin 11.	Uncharacterized protein.	0.975
IL11	IL6R	ENSAMEP00000003958	ENSAMEP00000012289	Interleukin 11.	Interleukin 6 receptor.	0.912
IL11	IL6ST	ENSAMEP00000003958	ENSAMEP00000003839	Interleukin 11.	Interleukin 6 signal transducer.	0.955
IL11	OSM	ENSAMEP00000003958	ENSAMEP00000008293	Interleukin 11.	Oncostatin M.	0.973