NLRP6 protein (Ailuropoda melanoleuca) - STRING interaction network

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second shell of interactors

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

NLRP6

NLR family pyrin domain containing 6. (880 aa)

Predicted Functional Partners:

PYCARD

0.957

G1LM70_AILME

0.864

MEFV

0.760

G1L0X5_AILME

0.669

NLRP1

0.630

IL18

0.576

MAVS

0.571

IL1B

0.503

PGGHG

0.485

GSDMD

0.443

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1L0X5_AILME	G1LM70_AILME	ENSAMEP00000000527	ENSAMEP00000008053	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.895
G1L0X5_AILME	GSDMD	ENSAMEP00000000527	ENSAMEP00000007000	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin D.	0.926
G1L0X5_AILME	IL18	ENSAMEP00000000527	ENSAMEP00000004279	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.829
G1L0X5_AILME	IL1B	ENSAMEP00000000527	ENSAMEP00000011295	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.925
G1L0X5_AILME	MEFV	ENSAMEP00000000527	ENSAMEP00000011160	Uncharacterized protein; Belongs to the peptidase C14A family.	MEFV innate immuity regulator, pyrin.	0.771
G1L0X5_AILME	NLRP1	ENSAMEP00000000527	ENSAMEP00000018180	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family pyrin domain containing 1.	0.771
G1L0X5_AILME	NLRP6	ENSAMEP00000000527	ENSAMEP00000003541	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family pyrin domain containing 6.	0.669
G1L0X5_AILME	PYCARD	ENSAMEP00000000527	ENSAMEP00000007547	Uncharacterized protein; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.984
G1LM70_AILME	G1L0X5_AILME	ENSAMEP00000008053	ENSAMEP00000000527	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.895
G1LM70_AILME	GSDMD	ENSAMEP00000008053	ENSAMEP00000007000	Uncharacterized protein.	Gasdermin D.	0.610
G1LM70_AILME	IL18	ENSAMEP00000008053	ENSAMEP00000004279	Uncharacterized protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.732
G1LM70_AILME	IL1B	ENSAMEP00000008053	ENSAMEP00000011295	Uncharacterized protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.680
G1LM70_AILME	MEFV	ENSAMEP00000008053	ENSAMEP00000011160	Uncharacterized protein.	MEFV innate immuity regulator, pyrin.	0.631
G1LM70_AILME	NLRP1	ENSAMEP00000008053	ENSAMEP00000018180	Uncharacterized protein.	NLR family pyrin domain containing 1.	0.485
G1LM70_AILME	NLRP6	ENSAMEP00000008053	ENSAMEP00000003541	Uncharacterized protein.	NLR family pyrin domain containing 6.	0.864
G1LM70_AILME	PYCARD	ENSAMEP00000008053	ENSAMEP00000007547	Uncharacterized protein.	PYD and CARD domain containing.	0.821
GSDMD	G1L0X5_AILME	ENSAMEP00000007000	ENSAMEP00000000527	Gasdermin D.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.926
GSDMD	G1LM70_AILME	ENSAMEP00000007000	ENSAMEP00000008053	Gasdermin D.	Uncharacterized protein.	0.610
GSDMD	IL18	ENSAMEP00000007000	ENSAMEP00000004279	Gasdermin D.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.765
GSDMD	IL1B	ENSAMEP00000007000	ENSAMEP00000011295	Gasdermin D.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.792