STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK12Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] (1491 aa)    
Predicted Functional Partners:
CCNT1
Cyclin T1; Belongs to the cyclin family.
   
 0.907
CCNT2
Cyclin T2; Belongs to the cyclin family.
   
 0.891
POLR2A
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.821
CCNH
Cyclin H; Belongs to the cyclin family.
    
 0.820
SUPT5H
Transcription elongation factor SPT5.
    
 0.803
CDK7
Cyclin dependent kinase 7; Belongs to the protein kinase superfamily.
    
0.730
CCNQ
Cyclin Q; Belongs to the cyclin family.
   
 0.730
C6orf15
Chromosome 6 open reading frame 15.
    
 0.716
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
   
 
 0.687
CCNL1
Cyclin L1; Belongs to the cyclin family.
      
 0.683
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.