IPO7 protein (Ailuropoda melanoleuca) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

IPO7

Importin 7. (1039 aa)

Predicted Functional Partners:

TNPO1

0.973

IPO5

0.970

KPNB1

0.950

IPO4

0.947

IPO9

0.937

TNPO2

0.927

IPO11

0.926

TNPO3

0.926

IPO13

0.902

AGO2

0.844

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	IPO7	ENSAMEP00000005384	ENSAMEP00000004207	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Importin 7.	0.844
IPO11	IPO13	ENSAMEP00000004340	ENSAMEP00000001206	Importin 11.	Importin 13.	0.908
IPO11	IPO4	ENSAMEP00000004340	ENSAMEP00000017234	Importin 11.	Importin 4.	0.951
IPO11	IPO5	ENSAMEP00000004340	ENSAMEP00000004108	Importin 11.	Importin 5.	0.930
IPO11	IPO7	ENSAMEP00000004340	ENSAMEP00000004207	Importin 11.	Importin 7.	0.926
IPO11	IPO9	ENSAMEP00000004340	ENSAMEP00000012723	Importin 11.	Importin 9.	0.922
IPO11	KPNB1	ENSAMEP00000004340	ENSAMEP00000004904	Importin 11.	Karyopherin subunit beta 1.	0.907
IPO11	TNPO1	ENSAMEP00000004340	ENSAMEP00000007548	Importin 11.	Transportin 1.	0.946
IPO11	TNPO2	ENSAMEP00000004340	ENSAMEP00000012828	Importin 11.	Transportin 2.	0.903
IPO11	TNPO3	ENSAMEP00000004340	ENSAMEP00000005450	Importin 11.	Transportin 3.	0.916
IPO13	IPO11	ENSAMEP00000001206	ENSAMEP00000004340	Importin 13.	Importin 11.	0.908
IPO13	IPO4	ENSAMEP00000001206	ENSAMEP00000017234	Importin 13.	Importin 4.	0.925
IPO13	IPO5	ENSAMEP00000001206	ENSAMEP00000004108	Importin 13.	Importin 5.	0.916
IPO13	IPO7	ENSAMEP00000001206	ENSAMEP00000004207	Importin 13.	Importin 7.	0.902
IPO13	IPO9	ENSAMEP00000001206	ENSAMEP00000012723	Importin 13.	Importin 9.	0.910
IPO13	KPNB1	ENSAMEP00000001206	ENSAMEP00000004904	Importin 13.	Karyopherin subunit beta 1.	0.890
IPO13	TNPO1	ENSAMEP00000001206	ENSAMEP00000007548	Importin 13.	Transportin 1.	0.911
IPO13	TNPO2	ENSAMEP00000001206	ENSAMEP00000012828	Importin 13.	Transportin 2.	0.914
IPO13	TNPO3	ENSAMEP00000001206	ENSAMEP00000005450	Importin 13.	Transportin 3.	0.895
IPO4	IPO11	ENSAMEP00000017234	ENSAMEP00000004340	Importin 4.	Importin 11.	0.951