IRS1 protein (Ailuropoda melanoleuca) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

IRS1

Insulin receptor substrate 1. (1107 aa)

Predicted Functional Partners:

PTPN11

0.903

GRB2

0.815

INSR

0.790

INS-IGF2

0.745

PIK3R1

0.742

LYN

0.737

EPOR

0.724

NTRK1

0.715

JAK2

0.707

G1MLY5_AILME

0.707

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPOR	G1MLY5_AILME	ENSAMEP00000011156	ENSAMEP00000020373	Erythropoietin receptor; Receptor for erythropoietin.	FERM_F1 domain-containing protein.	0.976
EPOR	GRB2	ENSAMEP00000011156	ENSAMEP00000009814	Erythropoietin receptor; Receptor for erythropoietin.	Growth factor receptor bound protein 2.	0.773
EPOR	IRS1	ENSAMEP00000011156	ENSAMEP00000004482	Erythropoietin receptor; Receptor for erythropoietin.	Insulin receptor substrate 1.	0.724
EPOR	JAK2	ENSAMEP00000011156	ENSAMEP00000010263	Erythropoietin receptor; Receptor for erythropoietin.	Tyrosine-protein kinase.	0.995
EPOR	LYN	ENSAMEP00000011156	ENSAMEP00000001862	Erythropoietin receptor; Receptor for erythropoietin.	Tyrosine-protein kinase.	0.955
EPOR	PIK3R1	ENSAMEP00000011156	ENSAMEP00000003218	Erythropoietin receptor; Receptor for erythropoietin.	Phosphoinositide-3-kinase regulatory subunit 1.	0.734
G1MLY5_AILME	EPOR	ENSAMEP00000020373	ENSAMEP00000011156	FERM_F1 domain-containing protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.976
G1MLY5_AILME	GRB2	ENSAMEP00000020373	ENSAMEP00000009814	FERM_F1 domain-containing protein.	Growth factor receptor bound protein 2.	0.736
G1MLY5_AILME	INS-IGF2	ENSAMEP00000020373	ENSAMEP00000002279	FERM_F1 domain-containing protein.	INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.557
G1MLY5_AILME	IRS1	ENSAMEP00000020373	ENSAMEP00000004482	FERM_F1 domain-containing protein.	Insulin receptor substrate 1.	0.707
G1MLY5_AILME	LYN	ENSAMEP00000020373	ENSAMEP00000001862	FERM_F1 domain-containing protein.	Tyrosine-protein kinase.	0.814
G1MLY5_AILME	PIK3R1	ENSAMEP00000020373	ENSAMEP00000003218	FERM_F1 domain-containing protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.521
G1MLY5_AILME	PTPN11	ENSAMEP00000020373	ENSAMEP00000009046	FERM_F1 domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.770
GRB2	EPOR	ENSAMEP00000009814	ENSAMEP00000011156	Growth factor receptor bound protein 2.	Erythropoietin receptor; Receptor for erythropoietin.	0.773
GRB2	G1MLY5_AILME	ENSAMEP00000009814	ENSAMEP00000020373	Growth factor receptor bound protein 2.	FERM_F1 domain-containing protein.	0.736
GRB2	INS-IGF2	ENSAMEP00000009814	ENSAMEP00000002279	Growth factor receptor bound protein 2.	INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.701
GRB2	INSR	ENSAMEP00000009814	ENSAMEP00000008683	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.967
GRB2	IRS1	ENSAMEP00000009814	ENSAMEP00000004482	Growth factor receptor bound protein 2.	Insulin receptor substrate 1.	0.815
GRB2	JAK2	ENSAMEP00000009814	ENSAMEP00000010263	Growth factor receptor bound protein 2.	Tyrosine-protein kinase.	0.736
GRB2	LYN	ENSAMEP00000009814	ENSAMEP00000001862	Growth factor receptor bound protein 2.	Tyrosine-protein kinase.	0.688