STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G1LCX6_AILMEMCU domain-containing protein. (335 aa)    
Predicted Functional Partners:
MICU1
Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...]
    
 0.965
SMDT1
Single-pass membrane protein with aspartate rich tail 1.
    
 0.958
MICU2
Mitochondrial calcium uptake 2.
    
 0.875
MCU
Mitochondrial calcium uniporter.
  
 
0.829
G1LVE3_AILME
Uncharacterized protein.
     
 0.690
MICU3
Uncharacterized protein.
     
 0.690
MCUR1
Mitochondrial calcium uniporter regulator 1.
    
 
 0.548
AFG3L2
AFG3 like matrix AAA peptidase subunit 2.
     
 0.498
SPG7
SPG7 matrix AAA peptidase subunit, paraplegin.
     
 0.491
PHB
Prohibitin.
     
 0.464
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.