| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APEX1 | FEN1 | ENSAMEP00000005721 | ENSAMEP00000021025 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Flap structure-specific endonuclease 1. | 0.971 |
| APEX1 | LIG1 | ENSAMEP00000005721 | ENSAMEP00000015978 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.957 |
| APEX1 | LIG3 | ENSAMEP00000005721 | ENSAMEP00000015336 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.679 |
| APEX1 | NEIL1 | ENSAMEP00000005721 | ENSAMEP00000008572 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Nei like DNA glycosylase 1. | 0.450 |
| APEX1 | NEIL2 | ENSAMEP00000005721 | ENSAMEP00000006535 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Nei like DNA glycosylase 2. | 0.452 |
| APEX1 | PARP1 | ENSAMEP00000005721 | ENSAMEP00000015307 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Poly [ADP-ribose] polymerase. | 0.693 |
| APEX1 | PNKP | ENSAMEP00000005721 | ENSAMEP00000014406 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Polynucleotide kinase 3'-phosphatase. | 0.562 |
| APEX1 | POLB | ENSAMEP00000005721 | ENSAMEP00000005454 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.958 |
| APEX1 | XRCC1 | ENSAMEP00000005721 | ENSAMEP00000004587 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | X-ray repair cross complementing 1. | 0.611 |
| FEN1 | APEX1 | ENSAMEP00000021025 | ENSAMEP00000005721 | Flap structure-specific endonuclease 1. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.971 |
| FEN1 | LIG1 | ENSAMEP00000021025 | ENSAMEP00000015978 | Flap structure-specific endonuclease 1. | DNA ligase. | 0.966 |
| FEN1 | LIG3 | ENSAMEP00000021025 | ENSAMEP00000015336 | Flap structure-specific endonuclease 1. | DNA ligase. | 0.829 |
| FEN1 | NEIL1 | ENSAMEP00000021025 | ENSAMEP00000008572 | Flap structure-specific endonuclease 1. | Nei like DNA glycosylase 1. | 0.783 |
| FEN1 | NEIL2 | ENSAMEP00000021025 | ENSAMEP00000006535 | Flap structure-specific endonuclease 1. | Nei like DNA glycosylase 2. | 0.536 |
| FEN1 | PARP1 | ENSAMEP00000021025 | ENSAMEP00000015307 | Flap structure-specific endonuclease 1. | Poly [ADP-ribose] polymerase. | 0.833 |
| FEN1 | PNKP | ENSAMEP00000021025 | ENSAMEP00000014406 | Flap structure-specific endonuclease 1. | Polynucleotide kinase 3'-phosphatase. | 0.501 |
| FEN1 | POLB | ENSAMEP00000021025 | ENSAMEP00000005454 | Flap structure-specific endonuclease 1. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.965 |
| FEN1 | XRCC1 | ENSAMEP00000021025 | ENSAMEP00000004587 | Flap structure-specific endonuclease 1. | X-ray repair cross complementing 1. | 0.860 |
| LIG1 | APEX1 | ENSAMEP00000015978 | ENSAMEP00000005721 | DNA ligase. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.957 |
| LIG1 | FEN1 | ENSAMEP00000015978 | ENSAMEP00000021025 | DNA ligase. | Flap structure-specific endonuclease 1. | 0.966 |