TLR3 protein (Ailuropoda melanoleuca) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TLR3

Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)

Predicted Functional Partners:

TRAF6

0.978

TAB2

0.970

RIPK1

0.956

MAP3K7

0.955

UNC93B1

0.954

TAB1

0.943

MYD88

0.925

TICAM1

0.900

CD4

0.856

TBK1

0.829

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	MYD88	ENSAMEP00000014814	ENSAMEP00000018773	Ig-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.868
CD4	TBK1	ENSAMEP00000014814	ENSAMEP00000019165	Ig-like domain-containing protein.	TANK binding kinase 1.	0.565
CD4	TLR3	ENSAMEP00000014814	ENSAMEP00000005478	Ig-like domain-containing protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.856
CD4	TRAF6	ENSAMEP00000014814	ENSAMEP00000014595	Ig-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.618
MAP3K7	MYD88	ENSAMEP00000003776	ENSAMEP00000018773	Mitogen-activated protein kinase kinase kinase 7.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.995
MAP3K7	RIPK1	ENSAMEP00000003776	ENSAMEP00000015161	Mitogen-activated protein kinase kinase kinase 7.	Receptor interacting serine/threonine kinase 1.	0.977
MAP3K7	TAB1	ENSAMEP00000003776	ENSAMEP00000011454	Mitogen-activated protein kinase kinase kinase 7.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.999
MAP3K7	TAB2	ENSAMEP00000003776	ENSAMEP00000019324	Mitogen-activated protein kinase kinase kinase 7.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.997
MAP3K7	TICAM1	ENSAMEP00000003776	ENSAMEP00000003611	Mitogen-activated protein kinase kinase kinase 7.	Toll like receptor adaptor molecule 1.	0.756
MAP3K7	TLR3	ENSAMEP00000003776	ENSAMEP00000005478	Mitogen-activated protein kinase kinase kinase 7.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.955
MAP3K7	TRAF6	ENSAMEP00000003776	ENSAMEP00000014595	Mitogen-activated protein kinase kinase kinase 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
MYD88	CD4	ENSAMEP00000018773	ENSAMEP00000014814	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Ig-like domain-containing protein.	0.868
MYD88	MAP3K7	ENSAMEP00000018773	ENSAMEP00000003776	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Mitogen-activated protein kinase kinase kinase 7.	0.995
MYD88	RIPK1	ENSAMEP00000018773	ENSAMEP00000015161	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Receptor interacting serine/threonine kinase 1.	0.561
MYD88	TAB1	ENSAMEP00000018773	ENSAMEP00000011454	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.945
MYD88	TAB2	ENSAMEP00000018773	ENSAMEP00000019324	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.647
MYD88	TBK1	ENSAMEP00000018773	ENSAMEP00000019165	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TANK binding kinase 1.	0.671
MYD88	TICAM1	ENSAMEP00000018773	ENSAMEP00000003611	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor adaptor molecule 1.	0.832
MYD88	TLR3	ENSAMEP00000018773	ENSAMEP00000005478	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.925
MYD88	TRAF6	ENSAMEP00000018773	ENSAMEP00000014595	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999