STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SREBF1Sterol regulatory element binding transcription factor 1. (1116 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
   
 0.958
SREBF2
Sterol regulatory element binding transcription factor 2.
  
 
0.928
KPNB1
Karyopherin subunit beta 1.
    
 0.871
MBTPS2
Membrane bound transcription factor peptidase, site 2.
    
 0.826
FASN
Fatty acid synthase.
   
 
 0.807
SCD
Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.
   
 
 0.786
NPC1
NPC intracellular cholesterol transporter 1.
   
 0.760
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.750
GRB14
Growth factor receptor bound protein 14.
      
 0.739
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
    
 0.731
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.