STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLE6TLE family member 6, subcortical maternal complex member. (453 aa)    
Predicted Functional Partners:
NLRP5
Uncharacterized protein.
    
 0.808
OOEP
Oocyte expressed protein.
    
 0.765
PADI6
Peptidyl arginine deiminase 6.
      
 0.631
NLRP9
NLR family pyrin domain containing 9.
    
 
 0.620
ANKRD24
Ankyrin repeat domain 24.
    
 
 0.599
WEE2
Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation ( [...]
      
 0.591
LEF1
Lymphoid enhancer binding factor 1.
    
 0.556
TCF7
Transcription factor 7.
    
 0.556
TCF7L1
Transcription factor 7 like 1.
    
 0.553
TCF7L2
Transcription factor 7 like 2.
    
 0.553
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.