STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RFX6DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide- producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] (928 aa)    
Predicted Functional Partners:
MLXIPL
MLX interacting protein like.
      
 0.750
INSM1
INSM transcriptional repressor 1.
      
 0.741
HHEX
Hematopoietically expressed homeobox.
      
 0.729
PCSK1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
      
 0.682
RFX7
Regulatory factor X7.
    
 
0.642
PAX4
Paired box 4.
   
  
 0.624
NEUROG2
Neurogenin 2.
   
  
 0.608
NEUROG3
Neurogenin 3.
   
  
 0.608
RFXAP
Regulatory factor X associated protein.
    
 
 0.549
SS18L1
SS18L1 subunit of BAF chromatin remodeling complex.
    
 
 0.538
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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