| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | CASP10 | ENSAMEP00000011364 | ENSAMEP00000006384 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 10; Belongs to the peptidase C14A family. | 0.771 |
| APAF1 | CASP2 | ENSAMEP00000011364 | ENSAMEP00000006965 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 2; Belongs to the peptidase C14A family. | 0.792 |
| APAF1 | CASP3 | ENSAMEP00000011364 | ENSAMEP00000008903 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 3; Belongs to the peptidase C14A family. | 0.995 |
| APAF1 | CASP8 | ENSAMEP00000011364 | ENSAMEP00000006404 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 8; Belongs to the peptidase C14A family. | 0.815 |
| APAF1 | CYCS | ENSAMEP00000011364 | ENSAMEP00000006361 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.997 |
| APAF1 | PIDD1 | ENSAMEP00000011364 | ENSAMEP00000007311 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | P53-induced death domain protein 1. | 0.605 |
| APAF1 | XIAP | ENSAMEP00000011364 | ENSAMEP00000016676 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | X-linked inhibitor of apoptosis. | 0.926 |
| APPL1 | APPL2 | ENSAMEP00000012361 | ENSAMEP00000007419 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | 0.998 |
| APPL1 | CASP10 | ENSAMEP00000012361 | ENSAMEP00000006384 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Caspase 10; Belongs to the peptidase C14A family. | 0.752 |
| APPL1 | CASP2 | ENSAMEP00000012361 | ENSAMEP00000006965 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Caspase 2; Belongs to the peptidase C14A family. | 0.752 |
| APPL1 | CASP3 | ENSAMEP00000012361 | ENSAMEP00000008903 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Caspase 3; Belongs to the peptidase C14A family. | 0.915 |
| APPL1 | CASP8 | ENSAMEP00000012361 | ENSAMEP00000006404 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Caspase 8; Belongs to the peptidase C14A family. | 0.752 |
| APPL2 | APPL1 | ENSAMEP00000007419 | ENSAMEP00000012361 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | 0.998 |
| APPL2 | CASP10 | ENSAMEP00000007419 | ENSAMEP00000006384 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Caspase 10; Belongs to the peptidase C14A family. | 0.752 |
| APPL2 | CASP2 | ENSAMEP00000007419 | ENSAMEP00000006965 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Caspase 2; Belongs to the peptidase C14A family. | 0.752 |
| APPL2 | CASP3 | ENSAMEP00000007419 | ENSAMEP00000008903 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Caspase 3; Belongs to the peptidase C14A family. | 0.752 |
| APPL2 | CASP8 | ENSAMEP00000007419 | ENSAMEP00000006404 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Caspase 8; Belongs to the peptidase C14A family. | 0.752 |
| BID | CASP10 | ENSAMEP00000018464 | ENSAMEP00000006384 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 10; Belongs to the peptidase C14A family. | 0.963 |
| BID | CASP2 | ENSAMEP00000018464 | ENSAMEP00000006965 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 2; Belongs to the peptidase C14A family. | 0.954 |
| BID | CASP3 | ENSAMEP00000018464 | ENSAMEP00000008903 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 3; Belongs to the peptidase C14A family. | 0.827 |
