CASP2 protein (Ailuropoda melanoleuca) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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Score

CASP2

Caspase 2; Belongs to the peptidase C14A family. (452 aa)

Predicted Functional Partners:

PIDD1

0.960

BID

0.948

APAF1

0.857

XIAP

0.729

BCL2

0.687

CYCS

0.685

BIRC6

0.680

GABPB1

0.678

CASP3

0.672

CENPN

0.666

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BCL2	ENSAMEP00000011364	ENSAMEP00000006680	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.916
APAF1	BID	ENSAMEP00000011364	ENSAMEP00000018464	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.471
APAF1	BIRC6	ENSAMEP00000011364	ENSAMEP00000008509	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 6.	0.835
APAF1	CASP2	ENSAMEP00000011364	ENSAMEP00000006965	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.857
APAF1	CASP3	ENSAMEP00000011364	ENSAMEP00000008903	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.992
APAF1	CYCS	ENSAMEP00000011364	ENSAMEP00000006361	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	XIAP	ENSAMEP00000011364	ENSAMEP00000016676	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	X-linked inhibitor of apoptosis.	0.847
BCL2	APAF1	ENSAMEP00000006680	ENSAMEP00000011364	BCL2 apoptosis regulator.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.916
BCL2	BID	ENSAMEP00000006680	ENSAMEP00000018464	BCL2 apoptosis regulator.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.987
BCL2	CASP2	ENSAMEP00000006680	ENSAMEP00000006965	BCL2 apoptosis regulator.	Caspase 2; Belongs to the peptidase C14A family.	0.687
BCL2	CASP3	ENSAMEP00000006680	ENSAMEP00000008903	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.866
BCL2	CYCS	ENSAMEP00000006680	ENSAMEP00000006361	BCL2 apoptosis regulator.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.865
BCL2	XIAP	ENSAMEP00000006680	ENSAMEP00000016676	BCL2 apoptosis regulator.	X-linked inhibitor of apoptosis.	0.775
BID	APAF1	ENSAMEP00000018464	ENSAMEP00000011364	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.471
BID	BCL2	ENSAMEP00000018464	ENSAMEP00000006680	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	BCL2 apoptosis regulator.	0.987
BID	CASP2	ENSAMEP00000018464	ENSAMEP00000006965	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase 2; Belongs to the peptidase C14A family.	0.948
BID	CASP3	ENSAMEP00000018464	ENSAMEP00000008903	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase 3; Belongs to the peptidase C14A family.	0.703
BID	CYCS	ENSAMEP00000018464	ENSAMEP00000006361	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.710
BID	PIDD1	ENSAMEP00000018464	ENSAMEP00000007311	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	P53-induced death domain protein 1.	0.911
BIRC6	APAF1	ENSAMEP00000008509	ENSAMEP00000011364	Baculoviral IAP repeat containing 6.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.835