IL15 protein (Ailuropoda melanoleuca) - STRING interaction network

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IL15

Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (159 aa)

Predicted Functional Partners:

IL15RA

0.996

IL2RG

0.995

IL2RB

0.993

CD4

0.951

IL7R

0.849

IL21R

0.801

JAK3

0.799

IL2RA

0.794

IL1B

0.786

IL4R

0.779

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	IL15	ENSAMEP00000014814	ENSAMEP00000008470	Ig-like domain-containing protein.	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	0.951
CD4	IL1B	ENSAMEP00000014814	ENSAMEP00000011295	Ig-like domain-containing protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.951
CD4	IL21R	ENSAMEP00000014814	ENSAMEP00000011755	Ig-like domain-containing protein.	Interleukin 21 receptor.	0.768
CD4	IL2RA	ENSAMEP00000014814	ENSAMEP00000002208	Ig-like domain-containing protein.	Interleukin 2 receptor subunit alpha.	0.782
CD4	IL2RB	ENSAMEP00000014814	ENSAMEP00000010378	Ig-like domain-containing protein.	Interleukin 2 receptor subunit beta.	0.403
CD4	IL2RG	ENSAMEP00000014814	ENSAMEP00000016793	Ig-like domain-containing protein.	Fibronectin type-III domain-containing protein.	0.400
CD4	IL4R	ENSAMEP00000014814	ENSAMEP00000004325	Ig-like domain-containing protein.	Interleukin 4 receptor.	0.576
CD4	IL7R	ENSAMEP00000014814	ENSAMEP00000002681	Ig-like domain-containing protein.	Interleukin 7 receptor.	0.781
CD4	JAK3	ENSAMEP00000014814	ENSAMEP00000011425	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.675
IL15	CD4	ENSAMEP00000008470	ENSAMEP00000014814	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Ig-like domain-containing protein.	0.951
IL15	IL15RA	ENSAMEP00000008470	ENSAMEP00000002203	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Sushi domain-containing protein.	0.996
IL15	IL1B	ENSAMEP00000008470	ENSAMEP00000011295	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.786
IL15	IL21R	ENSAMEP00000008470	ENSAMEP00000011755	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Interleukin 21 receptor.	0.801
IL15	IL2RA	ENSAMEP00000008470	ENSAMEP00000002208	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Interleukin 2 receptor subunit alpha.	0.794
IL15	IL2RB	ENSAMEP00000008470	ENSAMEP00000010378	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Interleukin 2 receptor subunit beta.	0.993
IL15	IL2RG	ENSAMEP00000008470	ENSAMEP00000016793	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Fibronectin type-III domain-containing protein.	0.995
IL15	IL4R	ENSAMEP00000008470	ENSAMEP00000004325	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Interleukin 4 receptor.	0.779
IL15	IL7R	ENSAMEP00000008470	ENSAMEP00000002681	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Interleukin 7 receptor.	0.849
IL15	JAK3	ENSAMEP00000008470	ENSAMEP00000011425	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	Tyrosine-protein kinase.	0.799
IL15RA	IL15	ENSAMEP00000002203	ENSAMEP00000008470	Sushi domain-containing protein.	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family.	0.996

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