STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPINT2Serine peptidase inhibitor, Kunitz type 2. (255 aa)    
Predicted Functional Partners:
HGF
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.884
TMPRSS11E
Transmembrane protease serine; Belongs to the peptidase S1 family.
   
 0.802
SPINT4
Serine peptidase inhibitor, Kunitz type 4.
      
 0.704
HGFAC
HGF activator.
    
 0.647
MST1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.637
RASGRP4
RAS guanyl releasing protein 4.
      
 0.573
G1LI59_AILME
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.551
G1LI64_AILME
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.551
LOC100472031
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.551
LOC100464714
Uncharacterized protein.
  
   
0.540
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.