| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COPS5 | CUL1 | ENSAMEP00000013219 | ENSAMEP00000003070 | COP9 signalosome subunit 5. | Cullin 1; Belongs to the cullin family. | 0.985 |
| COPS5 | CUL3 | ENSAMEP00000013219 | ENSAMEP00000012279 | COP9 signalosome subunit 5. | Cullin 3; Belongs to the cullin family. | 0.983 |
| COPS5 | NAE1 | ENSAMEP00000013219 | ENSAMEP00000018080 | COP9 signalosome subunit 5. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.616 |
| COPS5 | NEDD8 | ENSAMEP00000013219 | ENSAMEP00000017137 | COP9 signalosome subunit 5. | NEDD8 ubiquitin like modifier. | 0.975 |
| COPS5 | RBX1 | ENSAMEP00000013219 | ENSAMEP00000014685 | COP9 signalosome subunit 5. | Ring-box 1. | 0.948 |
| COPS5 | SENP8 | ENSAMEP00000013219 | ENSAMEP00000021106 | COP9 signalosome subunit 5. | SUMO peptidase family member, NEDD8 specific. | 0.595 |
| COPS5 | UBA3 | ENSAMEP00000013219 | ENSAMEP00000010631 | COP9 signalosome subunit 5. | Ubiquitin like modifier activating enzyme 3. | 0.727 |
| COPS5 | UBE2F | ENSAMEP00000013219 | ENSAMEP00000009013 | COP9 signalosome subunit 5. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.741 |
| COPS5 | UBE2M | ENSAMEP00000013219 | ENSAMEP00000007972 | COP9 signalosome subunit 5. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.878 |
| CUL1 | COPS5 | ENSAMEP00000003070 | ENSAMEP00000013219 | Cullin 1; Belongs to the cullin family. | COP9 signalosome subunit 5. | 0.985 |
| CUL1 | CUL3 | ENSAMEP00000003070 | ENSAMEP00000012279 | Cullin 1; Belongs to the cullin family. | Cullin 3; Belongs to the cullin family. | 0.888 |
| CUL1 | NAE1 | ENSAMEP00000003070 | ENSAMEP00000018080 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.821 |
| CUL1 | NEDD8 | ENSAMEP00000003070 | ENSAMEP00000017137 | Cullin 1; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.990 |
| CUL1 | RBX1 | ENSAMEP00000003070 | ENSAMEP00000014685 | Cullin 1; Belongs to the cullin family. | Ring-box 1. | 0.998 |
| CUL1 | SENP8 | ENSAMEP00000003070 | ENSAMEP00000021106 | Cullin 1; Belongs to the cullin family. | SUMO peptidase family member, NEDD8 specific. | 0.876 |
| CUL1 | UBA3 | ENSAMEP00000003070 | ENSAMEP00000010631 | Cullin 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.922 |
| CUL1 | UBE2F | ENSAMEP00000003070 | ENSAMEP00000009013 | Cullin 1; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.895 |
| CUL1 | UBE2M | ENSAMEP00000003070 | ENSAMEP00000007972 | Cullin 1; Belongs to the cullin family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.978 |
| CUL3 | COPS5 | ENSAMEP00000012279 | ENSAMEP00000013219 | Cullin 3; Belongs to the cullin family. | COP9 signalosome subunit 5. | 0.983 |
| CUL3 | CUL1 | ENSAMEP00000012279 | ENSAMEP00000003070 | Cullin 3; Belongs to the cullin family. | Cullin 1; Belongs to the cullin family. | 0.888 |
