STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LIG4DNA ligase. (916 aa)    
Predicted Functional Partners:
XRCC5
X-ray repair cross complementing 5.
   
 0.988
XRCC6
X-ray repair cross complementing 6.
   
 0.987
NHEJ1
Non-homologous end joining factor 1.
    
 0.957
DCLRE1C
DNA cross-link repair 1C.
  
 0.940
XRCC1
X-ray repair cross complementing 1.
   
 0.910
PRKDC
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
 0.903
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.884
XRCC4
X-ray repair cross complementing 4.
    
 0.858
G1L496_AILME
Uncharacterized protein.
   
 0.854
MRE11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.840
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.