Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Dole_1908TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: sfu:Sfum_3896 isocitrate dehydrogenase, NADP-dependent. (413 aa)    
Predicted Functional Partners:
Dole_1003
PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: syw:SYNW2500 aconitate hydratase B; Belongs to the aconitase/IPM isomerase family.
  
 
 0.980
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.972
Dole_0693
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.964
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.932
Dole_1063
KEGG: sfu:Sfum_2105 citrate (Si)-synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family.
 
 0.918
Dole_1647
Glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: sat:SYN_02382 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.911
Dole_1065
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mbu:Mbur_0890 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein.
   
 
 0.907
Dole_3021
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: sfu:Sfum_1166 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
   
 
 0.907
Dole_3019
2-oxoglutarate synthase; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: mja:MJ0536 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit.
     
 0.906
Dole_3022
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sat:SYN_02497 ferridoxin.
     
 0.906
Your Current Organism:
Desulfococcus oleovorans
NCBI taxonomy Id: 96561
Other names: D. oleovorans Hxd3, Desulfobacteirum oleovorans Hxd3, Desulfococcus oleovorans Hxd3, delta proteobacterium Hxd3, sulfate-reducing bacterium Hxd3
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