STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (204 aa)    
Predicted Functional Partners:
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.971
OOV88874.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.852
dinB
Hypothetical protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.814
OOV87523.1
AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.752
OOV86213.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.666
OOV88183.1
4-hydroxyphenylacetate catabolism regulatory protein HpaA; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.534
OOV87438.1
DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.460
OOV86580.1
Hybrid sensor histidine kinase/response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.457
polA
Hypothetical protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.446
OOV86094.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.441
Your Current Organism:
Oceanospirillum linum
NCBI taxonomy Id: 966
Other names: ATCC 11336, CIP 103374, DSM 6292, IFO 15448, LMG 5214, LMG:5214, NBRC 15448, O. linum, Spirillum linum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.