| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDF11 | SMAD2 | ENSMPUP00000000876 | ENSMPUP00000000846 | Growth differentiation factor 11. | Mothers against decapentaplegic homolog. | 0.516 |
| GDF11 | SMAD3 | ENSMPUP00000000876 | ENSMPUP00000000302 | Growth differentiation factor 11. | Mothers against decapentaplegic homolog. | 0.500 |
| GDF11 | SMAD4 | ENSMPUP00000000876 | ENSMPUP00000008705 | Growth differentiation factor 11. | Mothers against decapentaplegic homolog. | 0.508 |
| GDF11 | TGFBR1 | ENSMPUP00000000876 | ENSMPUP00000006622 | Growth differentiation factor 11. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.984 |
| SMAD2 | GDF11 | ENSMPUP00000000846 | ENSMPUP00000000876 | Mothers against decapentaplegic homolog. | Growth differentiation factor 11. | 0.516 |
| SMAD2 | SMAD3 | ENSMPUP00000000846 | ENSMPUP00000000302 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.988 |
| SMAD2 | SMAD4 | ENSMPUP00000000846 | ENSMPUP00000008705 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.996 |
| SMAD2 | SMAD7 | ENSMPUP00000000846 | ENSMPUP00000000838 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.988 |
| SMAD2 | SMURF1 | ENSMPUP00000000846 | ENSMPUP00000016451 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.890 |
| SMAD2 | SMURF2 | ENSMPUP00000000846 | ENSMPUP00000014624 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.967 |
| SMAD2 | TGFB1 | ENSMPUP00000000846 | ENSMPUP00000017540 | Mothers against decapentaplegic homolog. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.863 |
| SMAD2 | TGFB2 | ENSMPUP00000000846 | ENSMPUP00000004208 | Mothers against decapentaplegic homolog. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.711 |
| SMAD2 | TGFBR1 | ENSMPUP00000000846 | ENSMPUP00000006622 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.988 |
| SMAD2 | TGFBR2 | ENSMPUP00000000846 | ENSMPUP00000011860 | Mothers against decapentaplegic homolog. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.981 |
| SMAD3 | GDF11 | ENSMPUP00000000302 | ENSMPUP00000000876 | Mothers against decapentaplegic homolog. | Growth differentiation factor 11. | 0.500 |
| SMAD3 | SMAD2 | ENSMPUP00000000302 | ENSMPUP00000000846 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.988 |
| SMAD3 | SMAD4 | ENSMPUP00000000302 | ENSMPUP00000008705 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.995 |
| SMAD3 | SMAD7 | ENSMPUP00000000302 | ENSMPUP00000000838 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.987 |
| SMAD3 | SMURF1 | ENSMPUP00000000302 | ENSMPUP00000016451 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.875 |
| SMAD3 | SMURF2 | ENSMPUP00000000302 | ENSMPUP00000014624 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.962 |
