DCLRE1C protein (Mustela putorius) - STRING interaction network

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Score

DCLRE1C

DNA cross-link repair 1C. (691 aa)

Predicted Functional Partners:

XRCC5

0.985

XRCC6

0.978

PRKDC

0.975

LIG4

0.945

NHEJ1

0.834

MRE11

0.817

CPSF1

0.796

TP53BP1

0.777

SYMPK

0.776

ATM

0.759

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DCLRE1C	ENSMPUP00000005920	ENSMPUP00000000908	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1C.	0.759
ATM	LIG4	ENSMPUP00000005920	ENSMPUP00000018556	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA ligase.	0.767
ATM	MRE11	ENSMPUP00000005920	ENSMPUP00000012153	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.997
ATM	NHEJ1	ENSMPUP00000005920	ENSMPUP00000016460	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-homologous end joining factor 1.	0.626
ATM	PRKDC	ENSMPUP00000005920	ENSMPUP00000001012	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.782
ATM	TP53BP1	ENSMPUP00000005920	ENSMPUP00000010187	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.973
ATM	XRCC5	ENSMPUP00000005920	ENSMPUP00000016361	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 5.	0.910
ATM	XRCC6	ENSMPUP00000005920	ENSMPUP00000016279	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 6.	0.932
CPSF1	DCLRE1C	ENSMPUP00000006363	ENSMPUP00000000908	Cleavage and polyadenylation specific factor 1.	DNA cross-link repair 1C.	0.796
CPSF1	SYMPK	ENSMPUP00000006363	ENSMPUP00000005463	Cleavage and polyadenylation specific factor 1.	Symplekin.	0.998
DCLRE1C	ATM	ENSMPUP00000000908	ENSMPUP00000005920	DNA cross-link repair 1C.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.759
DCLRE1C	CPSF1	ENSMPUP00000000908	ENSMPUP00000006363	DNA cross-link repair 1C.	Cleavage and polyadenylation specific factor 1.	0.796
DCLRE1C	LIG4	ENSMPUP00000000908	ENSMPUP00000018556	DNA cross-link repair 1C.	DNA ligase.	0.945
DCLRE1C	MRE11	ENSMPUP00000000908	ENSMPUP00000012153	DNA cross-link repair 1C.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.817
DCLRE1C	NHEJ1	ENSMPUP00000000908	ENSMPUP00000016460	DNA cross-link repair 1C.	Non-homologous end joining factor 1.	0.834
DCLRE1C	PRKDC	ENSMPUP00000000908	ENSMPUP00000001012	DNA cross-link repair 1C.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.975
DCLRE1C	SYMPK	ENSMPUP00000000908	ENSMPUP00000005463	DNA cross-link repair 1C.	Symplekin.	0.776
DCLRE1C	TP53BP1	ENSMPUP00000000908	ENSMPUP00000010187	DNA cross-link repair 1C.	Tumor protein p53 binding protein 1.	0.777
DCLRE1C	XRCC5	ENSMPUP00000000908	ENSMPUP00000016361	DNA cross-link repair 1C.	X-ray repair cross complementing 5.	0.985
DCLRE1C	XRCC6	ENSMPUP00000000908	ENSMPUP00000016279	DNA cross-link repair 1C.	X-ray repair cross complementing 6.	0.978