AKT1 protein (Mustela putorius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BAD	ENSMPUP00000002136	ENSMPUP00000012854	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.916
AKT1	ILK	ENSMPUP00000002136	ENSMPUP00000005454	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin linked kinase.	0.899
AKT1	M3YEG5_MUSPF	ENSMPUP00000002136	ENSMPUP00000009722	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.897
AKT1	MDM2	ENSMPUP00000002136	ENSMPUP00000017394	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.906
AKT1	MTOR	ENSMPUP00000002136	ENSMPUP00000016325	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.927
AKT1	NOS3	ENSMPUP00000002136	ENSMPUP00000007524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.906
AKT1	PDPK1	ENSMPUP00000002136	ENSMPUP00000015198	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.935
AKT1	PIK3CA	ENSMPUP00000002136	ENSMPUP00000017099	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.911
AKT1	PIK3R1	ENSMPUP00000002136	ENSMPUP00000014610	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.897
AKT1	TSC1	ENSMPUP00000002136	ENSMPUP00000012397	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	TSC complex subunit 1.	0.910
BAD	AKT1	ENSMPUP00000012854	ENSMPUP00000002136	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.916
ILK	AKT1	ENSMPUP00000005454	ENSMPUP00000002136	Integrin linked kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.899
ILK	PIK3CA	ENSMPUP00000005454	ENSMPUP00000017099	Integrin linked kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.915
ILK	PIK3R1	ENSMPUP00000005454	ENSMPUP00000014610	Integrin linked kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.900
M3YEG5_MUSPF	AKT1	ENSMPUP00000009722	ENSMPUP00000002136	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.897
M3YEG5_MUSPF	MDM2	ENSMPUP00000009722	ENSMPUP00000017394	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.438
M3YEG5_MUSPF	MTOR	ENSMPUP00000009722	ENSMPUP00000016325	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.401
M3YEG5_MUSPF	PIK3CA	ENSMPUP00000009722	ENSMPUP00000017099	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.479
MDM2	AKT1	ENSMPUP00000017394	ENSMPUP00000002136	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.906
MDM2	M3YEG5_MUSPF	ENSMPUP00000017394	ENSMPUP00000009722	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.438