JAG1 protein (Mustela putorius) - STRING interaction network

Nodes:

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white nodes:
second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

JAG1

Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)

Predicted Functional Partners:

NOTCH1

0.997

NOTCH2

0.993

NOTCH3

0.992

NOTCH4

0.984

M3XSG7_MUSPF

0.891

M3XSG8_MUSPF

0.891

RBPJ

0.807

MAML1

0.744

ATOH1

0.726

MAML2

0.719

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	JAG1	ENSMPUP00000018969	ENSMPUP00000006461	Atonal bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.726
ATOH1	NOTCH1	ENSMPUP00000018969	ENSMPUP00000011233	Atonal bHLH transcription factor 1.	Notch receptor 1.	0.524
JAG1	ATOH1	ENSMPUP00000006461	ENSMPUP00000018969	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Atonal bHLH transcription factor 1.	0.726
JAG1	M3XSG7_MUSPF	ENSMPUP00000006461	ENSMPUP00000002017	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.891
JAG1	M3XSG8_MUSPF	ENSMPUP00000006461	ENSMPUP00000002018	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.891
JAG1	MAML1	ENSMPUP00000006461	ENSMPUP00000000682	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.744
JAG1	MAML2	ENSMPUP00000006461	ENSMPUP00000012200	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.719
JAG1	NOTCH1	ENSMPUP00000006461	ENSMPUP00000011233	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.997
JAG1	NOTCH2	ENSMPUP00000006461	ENSMPUP00000001388	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.993
JAG1	NOTCH3	ENSMPUP00000006461	ENSMPUP00000015983	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.992
JAG1	NOTCH4	ENSMPUP00000006461	ENSMPUP00000010033	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.984
JAG1	RBPJ	ENSMPUP00000006461	ENSMPUP00000016611	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.807
M3XSG7_MUSPF	JAG1	ENSMPUP00000002017	ENSMPUP00000006461	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.891
M3XSG7_MUSPF	MAML1	ENSMPUP00000002017	ENSMPUP00000000682	Uncharacterized protein.	Mastermind like transcriptional coactivator 1.	0.593
M3XSG7_MUSPF	MAML2	ENSMPUP00000002017	ENSMPUP00000012200	Uncharacterized protein.	Mastermind like transcriptional coactivator 2.	0.594
M3XSG7_MUSPF	NOTCH1	ENSMPUP00000002017	ENSMPUP00000011233	Uncharacterized protein.	Notch receptor 1.	0.980
M3XSG7_MUSPF	NOTCH2	ENSMPUP00000002017	ENSMPUP00000001388	Uncharacterized protein.	Notch receptor 2.	0.955
M3XSG7_MUSPF	NOTCH3	ENSMPUP00000002017	ENSMPUP00000015983	Uncharacterized protein.	Notch receptor 3.	0.959
M3XSG7_MUSPF	NOTCH4	ENSMPUP00000002017	ENSMPUP00000010033	Uncharacterized protein.	Notch receptor 4.	0.953
M3XSG7_MUSPF	RBPJ	ENSMPUP00000002017	ENSMPUP00000016611	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.663

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.794

expected number of edges:

16

PPI enrichment p-value:

0.00371

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051537

2 iron, 2 sulfur cluster binding

5 of 22

1.81

2.24

9.19e-06

GO:0016491

Oxidoreductase activity

8 of 384

0.78

0.62

0.0015

GO:0043167

Ion binding

9 of 811

0.5

0.35

0.0186

GO:0005488

Binding

11 of 1306

0.38

0.3

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2121

Mixed, incl. AMP-binding enzyme C-terminal domain, and 2Fe-2S

7 of 28

1.86

3.45

2.49e-09

CL:2124

Mixed, incl. Cytochrome P450, and Phosphopantetheine

5 of 11

2.11

3.14

2.72e-07

CL:2126

Phosphopantetheine, and Oxidoreductase NAD-binding domain

4 of 5

2.36

3.03

1.31e-06

CL:1521

Glutamate synthase activity, and Gas transport

2 of 6

1.98

0.8

0.0314

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00360

Phenylalanine metabolism

3 of 29

1.47

0.81

0.0192

map01120

Microbial metabolism in diverse environments

6 of 342

0.7

0.42

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0001

2Fe-2S

5 of 10

2.16

3.36

1.06e-07

KW-0408

Iron

6 of 61

1.45

1.87

3.13e-06

KW-0596

Phosphopantetheine

2 of 3

2.28

1.26

0.0045

KW-0479

Metal-binding

6 of 219

0.9

0.71

0.0021

KW-0349

Heme

2 of 13

1.64

0.71

0.0385

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00111

2Fe-2S iron-sulfur cluster binding domain

5 of 10

2.16

3.19

2.62e-07

PF00970

Oxidoreductase FAD-binding domain

4 of 4

2.46

3.06

1.39e-06

PF00175

Oxidoreductase NAD-binding domain

4 of 4

2.46

3.06

1.39e-06

PF00550

Phosphopantetheine attachment site

2 of 3

2.28

1.01

0.0138

PF00067

Cytochrome P450

2 of 3

2.28

1.01

0.0138

(more ...)

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