PSMB10 protein (Mustela putorius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PSMB10

Proteasome subunit beta. (278 aa)

Predicted Functional Partners:

PSMB9

0.999

PSMB4

0.999

PSMB1

0.999

PSMA6

0.999

PSMA2

0.999

PSMA5

0.992

PSMB2

0.991

PSME2

0.988

PSMA1

0.988

PSMA3

0.985

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSMA1	PSMA2	ENSMPUP00000013101	ENSMPUP00000018034	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA1	PSMA3	ENSMPUP00000013101	ENSMPUP00000006075	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA1	PSMA5	ENSMPUP00000013101	ENSMPUP00000003156	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA1	PSMA6	ENSMPUP00000013101	ENSMPUP00000016185	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA1	PSMB1	ENSMPUP00000013101	ENSMPUP00000007093	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
PSMA1	PSMB10	ENSMPUP00000013101	ENSMPUP00000006733	Proteasome subunit alpha type.	Proteasome subunit beta.	0.988
PSMA1	PSMB2	ENSMPUP00000013101	ENSMPUP00000014780	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
PSMA1	PSMB4	ENSMPUP00000013101	ENSMPUP00000003695	Proteasome subunit alpha type.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.999
PSMA1	PSMB9	ENSMPUP00000013101	ENSMPUP00000001924	Proteasome subunit alpha type.	Proteasome subunit beta.	0.997
PSMA1	PSME2	ENSMPUP00000013101	ENSMPUP00000005930	Proteasome subunit alpha type.	Proteasome activator subunit 2.	0.996
PSMA2	PSMA1	ENSMPUP00000018034	ENSMPUP00000013101	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA2	PSMA3	ENSMPUP00000018034	ENSMPUP00000006075	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA2	PSMA5	ENSMPUP00000018034	ENSMPUP00000003156	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA2	PSMA6	ENSMPUP00000018034	ENSMPUP00000016185	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.999
PSMA2	PSMB1	ENSMPUP00000018034	ENSMPUP00000007093	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
PSMA2	PSMB10	ENSMPUP00000018034	ENSMPUP00000006733	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
PSMA2	PSMB2	ENSMPUP00000018034	ENSMPUP00000014780	Proteasome subunit alpha type.	Proteasome subunit beta.	0.999
PSMA2	PSMB4	ENSMPUP00000018034	ENSMPUP00000003695	Proteasome subunit alpha type.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.999
PSMA2	PSMB9	ENSMPUP00000018034	ENSMPUP00000001924	Proteasome subunit alpha type.	Proteasome subunit beta.	0.996
PSMA2	PSME2	ENSMPUP00000018034	ENSMPUP00000005930	Proteasome subunit alpha type.	Proteasome activator subunit 2.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.817

expected number of edges:

117

PPI enrichment p-value:

1

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098869

Cellular oxidant detoxification

8 of 33

2.57

7.61

3.11e-16

GO:0045454

Cell redox homeostasis

4 of 13

2.67

3.74

9.32e-08

GO:0006979

Response to oxidative stress

5 of 73

2.02

3.02

3.00e-07

GO:0034599

Cellular response to oxidative stress

4 of 33

2.27

2.88

2.06e-06

GO:0010035

Response to inorganic substance

4 of 86

1.85

2.05

3.91e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016209

Antioxidant activity

8 of 40

2.49

7.32

5.66e-16

GO:0004601

Peroxidase activity

4 of 17

2.56

3.39

3.73e-07

GO:0004784

Superoxide dismutase activity

3 of 6

2.88

2.89

5.14e-06

GO:0051920

Peroxiredoxin activity

3 of 7

2.82

2.87

5.24e-06

GO:0016491

Oxidoreductase activity

8 of 616

1.3

1.74

3.73e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000123

Histone acetyltransferase complex

2 of 24

2.11

0.71

0.0476

GO:0005739

Mitochondrion

5 of 583

1.12

0.7

0.0150

GO:0070013

Intracellular organelle lumen

4 of 585

1.02

0.52

0.0476

GO:0043231

Intracellular membrane-bounded organelle

9 of 4332

0.5

0.31

0.0476

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9327

Detoxification of Reactive Oxygen Species, and Peroxiredoxin, AhpC-type

7 of 21

2.71

7.18

9.63e-15

CL:9329

Cell redox homeostasis, and Protein repair

3 of 11

2.62

2.45

2.85e-05

CL:9356

Superoxide dismutase activity, and DJ-1/PfpI family

2 of 5

2.79

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

5 of 112

1.84

2.62

8.63e-07

map00480

Glutathione metabolism

4 of 86

1.85

2.19

1.59e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3299685

Detoxification of Reactive Oxygen Species

5 of 26

2.47

4.33

3.27e-09

MAP-9711123

Cellular response to chemical stress

7 of 117

1.96

3.96

3.01e-10

MAP-8953897

Cellular responses to stimuli

7 of 401

1.43

1.99

4.45e-07

MAP-2262752

Cellular responses to stress

7 of 401

1.43

1.99

4.45e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

3 of 156

1.47

0.74

0.0286

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10417

C-terminal domain of 1-Cys peroxiredoxin

2 of 2

3.19

1.39

0.0031

PF02777

Iron/manganese superoxide dismutases, C-terminal domain

2 of 2

3.19

1.39

0.0031

PF00578

AhpC/TSA family

2 of 9

2.53

1.1

0.0096

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024706

Peroxiredoxin, AhpC-type

3 of 3

3.19

2.66

1.50e-05

IPR000866

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

3 of 8

2.76

2.29

6.18e-05

IPR045020

1-Cys peroxiredoxin

2 of 2

3.19

1.54

0.0017

IPR036314

Manganese/iron superoxide dismutase, C-terminal domain superfamily

2 of 2

3.19

1.54

0.0017

IPR019832

Manganese/iron superoxide dismutase, C-terminal

2 of 2

3.19

1.54

0.0017

(more ...)

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