ZDHHC7 protein (Mustela putorius) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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Score

ZDHHC7

Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)

Predicted Functional Partners:

KIAA0513

0.635

ZDHHC8

0.573

ZDHHC13

0.561

ZDHHC5

0.544

LYPLA2

0.518

ABHD17B

0.516

PIN4

0.512

M3Z3N7_MUSPF

0.512

GUK1

0.511

RASSF3

0.511

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD17B	LYPLA2	ENSMPUP00000008908	ENSMPUP00000015753	Abhydrolase domain containing 17B.	Lysophospholipase 2.	0.666
ABHD17B	ZDHHC5	ENSMPUP00000008908	ENSMPUP00000000271	Abhydrolase domain containing 17B.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.511
ABHD17B	ZDHHC7	ENSMPUP00000008908	ENSMPUP00000008649	Abhydrolase domain containing 17B.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.516
GUK1	M3Z3N7_MUSPF	ENSMPUP00000001003	ENSMPUP00000018199	Guanylate kinase 1.	Ferric oxidoreductase domain-containing protein.	0.535
GUK1	PIN4	ENSMPUP00000001003	ENSMPUP00000005249	Guanylate kinase 1.	Peptidyl-prolyl cis-trans isomerase.	0.562
GUK1	ZDHHC7	ENSMPUP00000001003	ENSMPUP00000008649	Guanylate kinase 1.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.511
KIAA0513	ZDHHC7	ENSMPUP00000008640	ENSMPUP00000008649	KIAA0513.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.635
LYPLA2	ABHD17B	ENSMPUP00000015753	ENSMPUP00000008908	Lysophospholipase 2.	Abhydrolase domain containing 17B.	0.666
LYPLA2	ZDHHC13	ENSMPUP00000015753	ENSMPUP00000013739	Lysophospholipase 2.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.511
LYPLA2	ZDHHC5	ENSMPUP00000015753	ENSMPUP00000000271	Lysophospholipase 2.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.534
LYPLA2	ZDHHC7	ENSMPUP00000015753	ENSMPUP00000008649	Lysophospholipase 2.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.518
LYPLA2	ZDHHC8	ENSMPUP00000015753	ENSMPUP00000004142	Lysophospholipase 2.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.529
M3Z3N7_MUSPF	GUK1	ENSMPUP00000018199	ENSMPUP00000001003	Ferric oxidoreductase domain-containing protein.	Guanylate kinase 1.	0.535
M3Z3N7_MUSPF	PIN4	ENSMPUP00000018199	ENSMPUP00000005249	Ferric oxidoreductase domain-containing protein.	Peptidyl-prolyl cis-trans isomerase.	0.618
M3Z3N7_MUSPF	ZDHHC7	ENSMPUP00000018199	ENSMPUP00000008649	Ferric oxidoreductase domain-containing protein.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.512
PIN4	GUK1	ENSMPUP00000005249	ENSMPUP00000001003	Peptidyl-prolyl cis-trans isomerase.	Guanylate kinase 1.	0.562
PIN4	M3Z3N7_MUSPF	ENSMPUP00000005249	ENSMPUP00000018199	Peptidyl-prolyl cis-trans isomerase.	Ferric oxidoreductase domain-containing protein.	0.618
PIN4	ZDHHC7	ENSMPUP00000005249	ENSMPUP00000008649	Peptidyl-prolyl cis-trans isomerase.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.512
RASSF3	ZDHHC7	ENSMPUP00000017415	ENSMPUP00000008649	Ras association domain family member 3.	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	0.511
ZDHHC13	LYPLA2	ENSMPUP00000013739	ENSMPUP00000015753	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.	Lysophospholipase 2.	0.511

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

5 of 81

1.2

0.94

0.0035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2296

UbiC transcription regulator-associated

3 of 5

2.19

1.65

0.0011

CL:1696

Duplicated hybrid motif, and Glucose permease domain IIB

3 of 12

1.81

1.29

0.0034

CL:1699

Glucose permease domain IIB

2 of 6

1.94

0.89

0.0256

CL:1685

Import into cell, and Hydrolase activity, hydrolyzing O-glycosyl compounds

4 of 120

0.94

0.53

0.0377

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0598

Phosphotransferase system

3 of 27

1.46

1.02

0.0066

KW-0805

Transcription regulation

5 of 96

1.13

0.91

0.0026

KW-0762

Sugar transport

3 of 35

1.35

0.89

0.0107

KW-0238

DNA-binding

5 of 146

0.95

0.69

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

3 of 12

1.81

1.18

0.0059

PF02378

Phosphotransferase system, EIIC

3 of 24

1.51

0.86

0.0186

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR028978

Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain superfamily

4 of 11

1.98

2.01

0.00013

IPR011663

UbiC transcription regulator-associated

4 of 11

1.98

2.01

0.00013

IPR000524

Transcription regulator HTH, GntR

4 of 14

1.87

1.94

0.00013

IPR036878

Glucose permease domain IIB

3 of 12

1.81

1.25

0.0042

IPR018113

Phosphotransferase system EIIB, cysteine phosphorylation site

3 of 12

1.81

1.25

0.0042

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00866

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.

4 of 11

1.98

2.46

1.19e-05

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

4 of 14

1.87

2.34

1.33e-05

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