ROPN1L protein (Mustela putorius) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ROPN1L

Rhophilin associated tail protein 1 like. (218 aa)

Predicted Functional Partners:

WDR78

0.650

SPAG6

0.638

SCRG1

0.620

AKAP3

0.550

SNTN

0.549

AKAP4

0.528

TMCO5A

0.523

CABS1

0.514

IQCN

0.496

MARCHF6

0.486

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP3	CABS1	ENSMPUP00000009099	ENSMPUP00000018953	A-kinase anchoring protein 3.	Calcium binding protein, spermatid associated 1.	0.526
AKAP3	ROPN1L	ENSMPUP00000009099	ENSMPUP00000011132	A-kinase anchoring protein 3.	Rhophilin associated tail protein 1 like.	0.550
AKAP3	SPAG6	ENSMPUP00000009099	ENSMPUP00000011975	A-kinase anchoring protein 3.	Sperm associated antigen 6.	0.526
AKAP4	CABS1	ENSMPUP00000013984	ENSMPUP00000018953	A-kinase anchoring protein 4.	Calcium binding protein, spermatid associated 1.	0.497
AKAP4	ROPN1L	ENSMPUP00000013984	ENSMPUP00000011132	A-kinase anchoring protein 4.	Rhophilin associated tail protein 1 like.	0.528
AKAP4	SPAG6	ENSMPUP00000013984	ENSMPUP00000011975	A-kinase anchoring protein 4.	Sperm associated antigen 6.	0.748
CABS1	AKAP3	ENSMPUP00000018953	ENSMPUP00000009099	Calcium binding protein, spermatid associated 1.	A-kinase anchoring protein 3.	0.526
CABS1	AKAP4	ENSMPUP00000018953	ENSMPUP00000013984	Calcium binding protein, spermatid associated 1.	A-kinase anchoring protein 4.	0.497
CABS1	IQCN	ENSMPUP00000018953	ENSMPUP00000015481	Calcium binding protein, spermatid associated 1.	IQ motif containing N.	0.530
CABS1	ROPN1L	ENSMPUP00000018953	ENSMPUP00000011132	Calcium binding protein, spermatid associated 1.	Rhophilin associated tail protein 1 like.	0.514
CABS1	TMCO5A	ENSMPUP00000018953	ENSMPUP00000008155	Calcium binding protein, spermatid associated 1.	Transmembrane and coiled-coil domains 5A.	0.535
IQCN	CABS1	ENSMPUP00000015481	ENSMPUP00000018953	IQ motif containing N.	Calcium binding protein, spermatid associated 1.	0.530
IQCN	ROPN1L	ENSMPUP00000015481	ENSMPUP00000011132	IQ motif containing N.	Rhophilin associated tail protein 1 like.	0.496
IQCN	TMCO5A	ENSMPUP00000015481	ENSMPUP00000008155	IQ motif containing N.	Transmembrane and coiled-coil domains 5A.	0.517
MARCHF6	ROPN1L	ENSMPUP00000011136	ENSMPUP00000011132	Membrane associated ring-CH-type finger 6.	Rhophilin associated tail protein 1 like.	0.486
ROPN1L	AKAP3	ENSMPUP00000011132	ENSMPUP00000009099	Rhophilin associated tail protein 1 like.	A-kinase anchoring protein 3.	0.550
ROPN1L	AKAP4	ENSMPUP00000011132	ENSMPUP00000013984	Rhophilin associated tail protein 1 like.	A-kinase anchoring protein 4.	0.528
ROPN1L	CABS1	ENSMPUP00000011132	ENSMPUP00000018953	Rhophilin associated tail protein 1 like.	Calcium binding protein, spermatid associated 1.	0.514
ROPN1L	IQCN	ENSMPUP00000011132	ENSMPUP00000015481	Rhophilin associated tail protein 1 like.	IQ motif containing N.	0.496
ROPN1L	MARCHF6	ENSMPUP00000011132	ENSMPUP00000011136	Rhophilin associated tail protein 1 like.	Membrane associated ring-CH-type finger 6.	0.486

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.817

expected number of edges:

117

PPI enrichment p-value:

1

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098869

Cellular oxidant detoxification

8 of 33

2.57

7.61

3.11e-16

GO:0045454

Cell redox homeostasis

4 of 13

2.67

3.74

9.32e-08

GO:0006979

Response to oxidative stress

5 of 73

2.02

3.02

3.00e-07

GO:0034599

Cellular response to oxidative stress

4 of 33

2.27

2.88

2.06e-06

GO:0010035

Response to inorganic substance

4 of 86

1.85

2.05

3.91e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016209

Antioxidant activity

8 of 40

2.49

7.32

5.66e-16

GO:0004601

Peroxidase activity

4 of 17

2.56

3.39

3.73e-07

GO:0004784

Superoxide dismutase activity

3 of 6

2.88

2.89

5.14e-06

GO:0051920

Peroxiredoxin activity

3 of 7

2.82

2.87

5.24e-06

GO:0016491

Oxidoreductase activity

8 of 616

1.3

1.74

3.73e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000123

Histone acetyltransferase complex

2 of 24

2.11

0.71

0.0476

GO:0005739

Mitochondrion

5 of 583

1.12

0.7

0.0150

GO:0070013

Intracellular organelle lumen

4 of 585

1.02

0.52

0.0476

GO:0043231

Intracellular membrane-bounded organelle

9 of 4332

0.5

0.31

0.0476

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9327

Detoxification of Reactive Oxygen Species, and Peroxiredoxin, AhpC-type

7 of 21

2.71

7.18

9.63e-15

CL:9329

Cell redox homeostasis, and Protein repair

3 of 11

2.62

2.45

2.85e-05

CL:9356

Superoxide dismutase activity, and DJ-1/PfpI family

2 of 5

2.79

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

5 of 112

1.84

2.62

8.63e-07

map00480

Glutathione metabolism

4 of 86

1.85

2.19

1.59e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3299685

Detoxification of Reactive Oxygen Species

5 of 26

2.47

4.33

3.27e-09

MAP-9711123

Cellular response to chemical stress

7 of 117

1.96

3.96

3.01e-10

MAP-8953897

Cellular responses to stimuli

7 of 401

1.43

1.99

4.45e-07

MAP-2262752

Cellular responses to stress

7 of 401

1.43

1.99

4.45e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

3 of 156

1.47

0.74

0.0286

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10417

C-terminal domain of 1-Cys peroxiredoxin

2 of 2

3.19

1.39

0.0031

PF02777

Iron/manganese superoxide dismutases, C-terminal domain

2 of 2

3.19

1.39

0.0031

PF00578

AhpC/TSA family

2 of 9

2.53

1.1

0.0096

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024706

Peroxiredoxin, AhpC-type

3 of 3

3.19

2.66

1.50e-05

IPR000866

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

3 of 8

2.76

2.29

6.18e-05

IPR045020

1-Cys peroxiredoxin

2 of 2

3.19

1.54

0.0017

IPR036314

Manganese/iron superoxide dismutase, C-terminal domain superfamily

2 of 2

3.19

1.54

0.0017

IPR019832

Manganese/iron superoxide dismutase, C-terminal

2 of 2

3.19

1.54

0.0017

(more ...)

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