STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (780 aa)    
Predicted Functional Partners:
STAM
Signal transducing adaptor molecule.
   
0.998
STAM2
Signal transducing adaptor molecule 2.
   
0.997
TSG101
Tumor susceptibility 101.
    
 0.993
M3YFD0_MUSPF
Uncharacterized protein.
    
 0.981
EPS15
Epidermal growth factor receptor pathway substrate 15.
   
 0.969
USP8
Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.
   
 0.942
CHMP2A
Charged multivesicular body protein 2A.
    
 0.940
RPS27A
Ubiquitin-like domain-containing protein.
    
  0.926
EGFR
Receptor protein-tyrosine kinase.
    
 0.916
AP1G2
AP-1 complex subunit gamma.
   
 0.871
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.