node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACMSD | HAAO | ENSMPUP00000002523 | ENSMPUP00000011433 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | 3-hydroxyanthranilate 3,4-dioxygenase. | 0.986 |
ACMSD | KMO | ENSMPUP00000002523 | ENSMPUP00000015590 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.841 |
ACMSD | KYNU | ENSMPUP00000002523 | ENSMPUP00000003655 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.888 |
ACMSD | M3YNK1_MUSPF | ENSMPUP00000002523 | ENSMPUP00000012908 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | Aminotran_1_2 domain-containing protein. | 0.554 |
ACMSD | QPRT | ENSMPUP00000002523 | ENSMPUP00000012343 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.812 |
ACMSD | TDO2 | ENSMPUP00000002523 | ENSMPUP00000005684 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.597 |
CAT | HAAO | ENSMPUP00000011568 | ENSMPUP00000011433 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | 3-hydroxyanthranilate 3,4-dioxygenase. | 0.934 |
CAT | KYNU | ENSMPUP00000011568 | ENSMPUP00000003655 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.942 |
CAT | NNT | ENSMPUP00000011568 | ENSMPUP00000014304 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | Nicotinamide nucleotide transhydrogenase. | 0.680 |
HAAO | ACMSD | ENSMPUP00000011433 | ENSMPUP00000002523 | 3-hydroxyanthranilate 3,4-dioxygenase. | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | 0.986 |
HAAO | CAT | ENSMPUP00000011433 | ENSMPUP00000011568 | 3-hydroxyanthranilate 3,4-dioxygenase. | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | 0.934 |
HAAO | IDO2 | ENSMPUP00000011433 | ENSMPUP00000005789 | 3-hydroxyanthranilate 3,4-dioxygenase. | Indoleamine 2,3-dioxygenase 2. | 0.770 |
HAAO | KMO | ENSMPUP00000011433 | ENSMPUP00000015590 | 3-hydroxyanthranilate 3,4-dioxygenase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.900 |
HAAO | KYNU | ENSMPUP00000011433 | ENSMPUP00000003655 | 3-hydroxyanthranilate 3,4-dioxygenase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.991 |
HAAO | M3YNK1_MUSPF | ENSMPUP00000011433 | ENSMPUP00000012908 | 3-hydroxyanthranilate 3,4-dioxygenase. | Aminotran_1_2 domain-containing protein. | 0.563 |
HAAO | NNT | ENSMPUP00000011433 | ENSMPUP00000014304 | 3-hydroxyanthranilate 3,4-dioxygenase. | Nicotinamide nucleotide transhydrogenase. | 0.618 |
HAAO | QPRT | ENSMPUP00000011433 | ENSMPUP00000012343 | 3-hydroxyanthranilate 3,4-dioxygenase. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.781 |
HAAO | SULT1C3 | ENSMPUP00000011433 | ENSMPUP00000010702 | 3-hydroxyanthranilate 3,4-dioxygenase. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.545 |
HAAO | TDO2 | ENSMPUP00000011433 | ENSMPUP00000005684 | 3-hydroxyanthranilate 3,4-dioxygenase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.669 |
IDO2 | HAAO | ENSMPUP00000005789 | ENSMPUP00000011433 | Indoleamine 2,3-dioxygenase 2. | 3-hydroxyanthranilate 3,4-dioxygenase. | 0.770 |