LRSAM1 protein (Mustela putorius) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LRSAM1

Leucine rich repeat and sterile alpha motif containing 1. (727 aa)

Predicted Functional Partners:

STK25

0.812

STK26

0.809

STK24

0.809

CALCOCO2

0.766

RNF166

0.749

ADGRL3

0.748

ADGRL1

0.748

ADGRL2

0.748

TSG101

0.728

TRIM21

0.667

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRL1	LRSAM1	ENSMPUP00000003034	ENSMPUP00000013724	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and sterile alpha motif containing 1.	0.748
ADGRL2	LRSAM1	ENSMPUP00000010646	ENSMPUP00000013724	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and sterile alpha motif containing 1.	0.748
ADGRL3	LRSAM1	ENSMPUP00000001351	ENSMPUP00000013724	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat and sterile alpha motif containing 1.	0.748
CALCOCO2	LRSAM1	ENSMPUP00000015228	ENSMPUP00000013724	Calcium binding and coiled-coil domain 2.	Leucine rich repeat and sterile alpha motif containing 1.	0.766
LRSAM1	ADGRL1	ENSMPUP00000013724	ENSMPUP00000003034	Leucine rich repeat and sterile alpha motif containing 1.	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	0.748
LRSAM1	ADGRL2	ENSMPUP00000013724	ENSMPUP00000010646	Leucine rich repeat and sterile alpha motif containing 1.	Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.	0.748
LRSAM1	ADGRL3	ENSMPUP00000013724	ENSMPUP00000001351	Leucine rich repeat and sterile alpha motif containing 1.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.748
LRSAM1	CALCOCO2	ENSMPUP00000013724	ENSMPUP00000015228	Leucine rich repeat and sterile alpha motif containing 1.	Calcium binding and coiled-coil domain 2.	0.766
LRSAM1	RNF166	ENSMPUP00000013724	ENSMPUP00000008019	Leucine rich repeat and sterile alpha motif containing 1.	Ring finger protein 166.	0.749
LRSAM1	STK24	ENSMPUP00000013724	ENSMPUP00000011495	Leucine rich repeat and sterile alpha motif containing 1.	Serine/threonine kinase 24.	0.809
LRSAM1	STK25	ENSMPUP00000013724	ENSMPUP00000000173	Leucine rich repeat and sterile alpha motif containing 1.	Serine/threonine kinase 25.	0.812
LRSAM1	STK26	ENSMPUP00000013724	ENSMPUP00000002098	Leucine rich repeat and sterile alpha motif containing 1.	Serine/threonine kinase 26.	0.809
LRSAM1	TRIM21	ENSMPUP00000013724	ENSMPUP00000010427	Leucine rich repeat and sterile alpha motif containing 1.	Tripartite motif containing 21.	0.667
LRSAM1	TSG101	ENSMPUP00000013724	ENSMPUP00000013666	Leucine rich repeat and sterile alpha motif containing 1.	Tumor susceptibility 101.	0.728
RNF166	LRSAM1	ENSMPUP00000008019	ENSMPUP00000013724	Ring finger protein 166.	Leucine rich repeat and sterile alpha motif containing 1.	0.749
RNF166	TRIM21	ENSMPUP00000008019	ENSMPUP00000010427	Ring finger protein 166.	Tripartite motif containing 21.	0.469
STK24	LRSAM1	ENSMPUP00000011495	ENSMPUP00000013724	Serine/threonine kinase 24.	Leucine rich repeat and sterile alpha motif containing 1.	0.809
STK24	STK25	ENSMPUP00000011495	ENSMPUP00000000173	Serine/threonine kinase 24.	Serine/threonine kinase 25.	0.870
STK25	LRSAM1	ENSMPUP00000000173	ENSMPUP00000013724	Serine/threonine kinase 25.	Leucine rich repeat and sterile alpha motif containing 1.	0.812
STK25	STK24	ENSMPUP00000000173	ENSMPUP00000011495	Serine/threonine kinase 25.	Serine/threonine kinase 24.	0.870

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

54

PPI enrichment p-value:

0.095

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

7 of 174

1.39

1.77

3.35e-06

GO:0000160

Phosphorelay signal transduction system

6 of 154

1.38

1.59

2.11e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 307

1.08

0.85

0.0025

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2736

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

9 of 62

1.95

5.23

4.43e-15

CL:2723

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

10 of 85

1.86

5.03

5.10e-16

CL:2741

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and HPT domain superfamily

8 of 56

1.94

4.71

4.34e-13

CL:2747

PAS-associated, C-terminal, and HPT domain superfamily

7 of 40

2.03

4.59

9.94e-12

CL:2702

Signal transduction histidine kinase-related protein, C-terminal, and Signaling

11 of 135

1.7

4.25

4.99e-16

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 522

0.91

0.79

0.00059

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030428

Cell septum

3 of 11

2.22

1.83

0.00032

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 182

1.48

2.67

1.11e-10

KW-0418

Kinase

5 of 232

1.12

0.9

0.0021

KW-0902

Two-component regulatory system

2 of 19

1.81

0.75

0.0355

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

9 of 174

1.5

2.63

6.23e-10

IPR011006

CheY-like superfamily

9 of 175

1.5

2.62

6.23e-10

IPR036641

HPT domain superfamily

3 of 7

2.42

2.11

0.00011

IPR003660

HAMP domain

3 of 17

2.03

1.62

0.00065

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 88

1.54

1.61

0.00011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 173

1.5

2.79

4.42e-11

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

3 of 18

2.01

1.91

0.00014

SM00388

His Kinase A (phosphoacceptor) domain

5 of 92

1.52

1.82

1.60e-05

SM00387

Histidine kinase-like ATPases

5 of 131

1.37

1.48

5.79e-05

SM00073

Histidine Phosphotransfer domain

2 of 6

2.31

1.47

0.0018

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About