DECR2 protein (Mustela putorius) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

DECR2

2,4-dienoyl-CoA reductase 2. (292 aa)

Predicted Functional Partners:

EVA1B

0.637

M3YXY4_MUSPF

0.583

ACADSB

0.566

OXSM

0.560

MCCC2

0.558

BDH2

0.541

EHHADH

0.539

ACADL

0.532

NME4

0.532

XPNPEP3

0.532

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADL	ACADSB	ENSMPUP00000007879	ENSMPUP00000002755	Acyl-CoA dehydrogenase long chain.	Acyl-CoA dehydrogenase short/branched chain.	0.939
ACADL	BDH2	ENSMPUP00000007879	ENSMPUP00000009169	Acyl-CoA dehydrogenase long chain.	3-hydroxybutyrate dehydrogenase 2.	0.432
ACADL	DECR2	ENSMPUP00000007879	ENSMPUP00000015909	Acyl-CoA dehydrogenase long chain.	2,4-dienoyl-CoA reductase 2.	0.532
ACADL	EHHADH	ENSMPUP00000007879	ENSMPUP00000002996	Acyl-CoA dehydrogenase long chain.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.978
ACADL	MCCC2	ENSMPUP00000007879	ENSMPUP00000014310	Acyl-CoA dehydrogenase long chain.	Methylcrotonoyl-CoA carboxylase 2.	0.727
ACADSB	ACADL	ENSMPUP00000002755	ENSMPUP00000007879	Acyl-CoA dehydrogenase short/branched chain.	Acyl-CoA dehydrogenase long chain.	0.939
ACADSB	DECR2	ENSMPUP00000002755	ENSMPUP00000015909	Acyl-CoA dehydrogenase short/branched chain.	2,4-dienoyl-CoA reductase 2.	0.566
ACADSB	EHHADH	ENSMPUP00000002755	ENSMPUP00000002996	Acyl-CoA dehydrogenase short/branched chain.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.973
ACADSB	MCCC2	ENSMPUP00000002755	ENSMPUP00000014310	Acyl-CoA dehydrogenase short/branched chain.	Methylcrotonoyl-CoA carboxylase 2.	0.587
ACADSB	OXSM	ENSMPUP00000002755	ENSMPUP00000012008	Acyl-CoA dehydrogenase short/branched chain.	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.417
BDH2	ACADL	ENSMPUP00000009169	ENSMPUP00000007879	3-hydroxybutyrate dehydrogenase 2.	Acyl-CoA dehydrogenase long chain.	0.432
BDH2	DECR2	ENSMPUP00000009169	ENSMPUP00000015909	3-hydroxybutyrate dehydrogenase 2.	2,4-dienoyl-CoA reductase 2.	0.541
BDH2	EHHADH	ENSMPUP00000009169	ENSMPUP00000002996	3-hydroxybutyrate dehydrogenase 2.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.423
BDH2	M3YXY4_MUSPF	ENSMPUP00000009169	ENSMPUP00000016194	3-hydroxybutyrate dehydrogenase 2.	PKS_AT domain-containing protein.	0.583
BDH2	OXSM	ENSMPUP00000009169	ENSMPUP00000012008	3-hydroxybutyrate dehydrogenase 2.	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.560
DECR2	ACADL	ENSMPUP00000015909	ENSMPUP00000007879	2,4-dienoyl-CoA reductase 2.	Acyl-CoA dehydrogenase long chain.	0.532
DECR2	ACADSB	ENSMPUP00000015909	ENSMPUP00000002755	2,4-dienoyl-CoA reductase 2.	Acyl-CoA dehydrogenase short/branched chain.	0.566
DECR2	BDH2	ENSMPUP00000015909	ENSMPUP00000009169	2,4-dienoyl-CoA reductase 2.	3-hydroxybutyrate dehydrogenase 2.	0.541
DECR2	EHHADH	ENSMPUP00000015909	ENSMPUP00000002996	2,4-dienoyl-CoA reductase 2.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.539
DECR2	EVA1B	ENSMPUP00000015909	ENSMPUP00000014672	2,4-dienoyl-CoA reductase 2.	Eva-1 homolog B.	0.637

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

13

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015833

Peptide transport

2 of 6

2.26

0.91

0.0210

GO:0006810

Transport

9 of 718

0.84

0.74

0.00027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

6 of 6

2.74

5.95

4.21e-12

GO:0022857

Transmembrane transporter activity

7 of 423

0.96

0.89

0.00019

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 977

0.75

0.71

1.56e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5129

Mixed, incl. Peptide transport, and Nickel cation transmembrane transporter activity

10 of 23

2.38

8.46

7.43e-20

CL:5131

Peptide transport, and Nickel cation transmembrane transporter activity

9 of 15

2.52

8.44

1.59e-18

CL:5151

Peptide transport, and Nickel cation transmembrane transporter activity

5 of 5

2.74

4.94

4.61e-10

CL:5132

Peptide transport, and Nickel cation transmembrane transporter activity

4 of 10

2.34

3.02

1.32e-06

CL:5142

Oligopeptide/dipeptide ABC transporter, C-terminal, and Nickel cation transmembrane transporter activity

2 of 5

2.34

1.04

0.0122

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02024

Quorum sensing

9 of 183

1.43

2.5

1.58e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

7 of 52

1.87

4.01

3.08e-11

MAP-9635486

Infection with Mycobacterium tuberculosis

7 of 81

1.68

3.22

2.82e-10

MAP-5663205

Infectious disease

7 of 87

1.65

3.12

3.02e-10

MAP-1643685

Disease

7 of 89

1.64

3.09

3.02e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 6

2.44

2.13

9.93e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 180

1.44

2.51

2.24e-10

KW-1003

Cell membrane

6 of 191

1.24

1.34

4.12e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

6 of 72

1.66

2.33

1.15e-06

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