STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
KCNIP2Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart. Required for normal protein levels of KCND2 in the heart ventricle (By similarity); Belongs to the recoverin family. (252 aa)    
Predicted Functional Partners:
KCND1
Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family.
    
 0.734
KCND3
BTB domain-containing protein; Belongs to the potassium channel family.
    
 0.717
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
    
 0.670
M3Y6Q5_MUSPF
DUF3399 domain-containing protein.
    
 0.582
KCND2
Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens t [...]
    
 0.582
DPP6
Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family.
    
 
 0.563
DPP10
Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family.
    
 
 0.550
KCNIP1
Potassium voltage-gated channel interacting protein 1.
  
 
0.550
VSTM5
V-set and transmembrane domain containing 5.
      
 0.531
RFK
Riboflavin kinase.
      
 0.519
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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