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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
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RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1028 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.
    
 0.995
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    
 0.990
GRB2
Growth factor receptor bound protein 2.
   
 0.979
GFRA3
GDNF family receptor alpha 3.
    
 0.976
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.973
GFRA4
GDNF family receptor alpha 4.
     
 0.960
GDNF
Glial cell derived neurotrophic factor.
    
 0.959
CCDC6
Coiled-coil domain containing 6.
     
 0.953
EGFR
Receptor protein-tyrosine kinase.
    
 0.953
FGF2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.949
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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