STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RASGRP4RAS guanyl releasing protein 4. (490 aa)    
Predicted Functional Partners:
M3YA60_MUSPF
N-terminal Ras-GEF domain-containing protein.
 
      0.891
MAGI3
Membrane associated guanylate kinase, WW and PDZ domain containing 3.
    
 0.589
M3XLU3_MUSPF
Uncharacterized protein.
   
 0.545
GRAP2
GRB2 related adaptor protein 2.
   
 0.545
GRB2
Growth factor receptor bound protein 2.
   
 0.545
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.537
MST1R
Macrophage stimulating 1 receptor.
    
 0.537
LRGUK
Leucine rich repeats and guanylate kinase domain containing.
    
 0.487
CRKL
CRK like proto-oncogene, adaptor protein.
    
 0.473
CRK
CRK proto-oncogene, adaptor protein.
    
 0.473
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.