node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tchl_1036 | Tchl_2264 | Tchl_1036 | Tchl_2264 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.800 |
Tchl_1036 | ilvA | Tchl_1036 | Tchl_1527 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.828 |
Tchl_1036 | trpA | Tchl_1036 | Tchl_3355 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.800 |
Tchl_1036 | trpB | Tchl_1036 | Tchl_0541 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Tryptophan synthase beta chain like; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.800 |
Tchl_1036 | trpB-2 | Tchl_1036 | Tchl_3356 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.819 |
Tchl_1364 | Tchl_1956 | Tchl_1364 | Tchl_1956 | Homoserine kinase. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.902 |
Tchl_1364 | Tchl_2264 | Tchl_1364 | Tchl_2264 | Homoserine kinase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.911 |
Tchl_1364 | Tchl_2646 | Tchl_1364 | Tchl_2646 | Homoserine kinase. | Phosphoserine phosphatase. | 0.904 |
Tchl_1364 | glyA | Tchl_1364 | Tchl_3309 | Homoserine kinase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
Tchl_1364 | ilvA | Tchl_1364 | Tchl_1527 | Homoserine kinase. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.910 |
Tchl_1364 | trpA | Tchl_1364 | Tchl_3355 | Homoserine kinase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.903 |
Tchl_1364 | trpB | Tchl_1364 | Tchl_0541 | Homoserine kinase. | Tryptophan synthase beta chain like; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
Tchl_1364 | trpB-2 | Tchl_1364 | Tchl_3356 | Homoserine kinase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.915 |
Tchl_1956 | Tchl_1364 | Tchl_1956 | Tchl_1364 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Homoserine kinase. | 0.902 |
Tchl_1956 | Tchl_2264 | Tchl_1956 | Tchl_2264 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
Tchl_1956 | Tchl_2646 | Tchl_1956 | Tchl_2646 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphoserine phosphatase. | 0.902 |
Tchl_1956 | glyA | Tchl_1956 | Tchl_3309 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.901 |
Tchl_1956 | ilvA | Tchl_1956 | Tchl_1527 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | L-threonine dehydratase biosynthetic IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.901 |
Tchl_1956 | trpA | Tchl_1956 | Tchl_3355 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
Tchl_1956 | trpB | Tchl_1956 | Tchl_0541 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase beta chain like; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |