node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tchl_2264 | gcvP | Tchl_2264 | Tchl_3046 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase [decarboxylating] (glycinecleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.645 |
Tchl_2264 | gcvP-2 | Tchl_2264 | Tchl_3145 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.645 |
Tchl_2264 | glyA | Tchl_2264 | Tchl_3309 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
Tchl_3048 | Tchl_3130 | Tchl_3048 | Tchl_3130 | Aminomethyltransferase. | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | 0.981 |
Tchl_3048 | folD | Tchl_3048 | Tchl_3123 | Aminomethyltransferase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
Tchl_3048 | gcvH | Tchl_3048 | Tchl_3045 | Aminomethyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
Tchl_3048 | gcvP | Tchl_3048 | Tchl_3046 | Aminomethyltransferase. | Glycine dehydrogenase [decarboxylating] (glycinecleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
Tchl_3048 | gcvP-2 | Tchl_3048 | Tchl_3145 | Aminomethyltransferase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
Tchl_3048 | glyA | Tchl_3048 | Tchl_3309 | Aminomethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
Tchl_3048 | purH | Tchl_3048 | Tchl_1836 | Aminomethyltransferase. | Bifunctional purine biosynthesis protein PurH. | 0.931 |
Tchl_3048 | purN | Tchl_3048 | Tchl_1045 | Aminomethyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
Tchl_3130 | Tchl_3048 | Tchl_3130 | Tchl_3048 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Aminomethyltransferase. | 0.981 |
Tchl_3130 | folD | Tchl_3130 | Tchl_3123 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.571 |
Tchl_3130 | gcvH | Tchl_3130 | Tchl_3045 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.985 |
Tchl_3130 | gcvP | Tchl_3130 | Tchl_3046 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Glycine dehydrogenase [decarboxylating] (glycinecleavage system P protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.971 |
Tchl_3130 | gcvP-2 | Tchl_3130 | Tchl_3145 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.971 |
Tchl_3130 | glyA | Tchl_3130 | Tchl_3309 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
Tchl_3130 | purL | Tchl_3130 | Tchl_3134 | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.561 |
folD | Tchl_3048 | Tchl_3123 | Tchl_3048 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase. | 0.945 |
folD | Tchl_3130 | Tchl_3123 | Tchl_3130 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Pyruvate dehydrogenase, dihydrolipoamide dehydrogenase. | 0.571 |