BACE1 protein (Felis catus) - STRING interaction network

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Score

BACE1

Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)

Predicted Functional Partners:

APP

0.968

RTN3

0.960

RTN4

0.952

BACE2

0.906

GGA1

0.892

IDE

0.885

APLP2

0.865

MMEL1

0.857

PSEN1

0.828

NRG1

0.784

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP2	APP	ENSFCAP00000008808	ENSFCAP00000001445	Amyloid beta precursor like protein 2.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.604
APLP2	BACE1	ENSFCAP00000008808	ENSFCAP00000000163	Amyloid beta precursor like protein 2.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.865
APLP2	BACE2	ENSFCAP00000008808	ENSFCAP00000001821	Amyloid beta precursor like protein 2.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.668
APLP2	IDE	ENSFCAP00000008808	ENSFCAP00000018455	Amyloid beta precursor like protein 2.	Insulin degrading enzyme.	0.627
APLP2	PSEN1	ENSFCAP00000008808	ENSFCAP00000048165	Amyloid beta precursor like protein 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.706
APP	APLP2	ENSFCAP00000001445	ENSFCAP00000008808	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Amyloid beta precursor like protein 2.	0.604
APP	BACE1	ENSFCAP00000001445	ENSFCAP00000000163	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 1; Belongs to the peptidase A1 family.	0.968
APP	BACE2	ENSFCAP00000001445	ENSFCAP00000001821	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 2; Belongs to the peptidase A1 family.	0.812
APP	IDE	ENSFCAP00000001445	ENSFCAP00000018455	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Insulin degrading enzyme.	0.949
APP	MMEL1	ENSFCAP00000001445	ENSFCAP00000008831	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Membrane metalloendopeptidase like 1.	0.731
APP	PSEN1	ENSFCAP00000001445	ENSFCAP00000048165	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.990
BACE1	APLP2	ENSFCAP00000000163	ENSFCAP00000008808	Beta-secretase 1; Belongs to the peptidase A1 family.	Amyloid beta precursor like protein 2.	0.865
BACE1	APP	ENSFCAP00000000163	ENSFCAP00000001445	Beta-secretase 1; Belongs to the peptidase A1 family.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.968
BACE1	BACE2	ENSFCAP00000000163	ENSFCAP00000001821	Beta-secretase 1; Belongs to the peptidase A1 family.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.906
BACE1	GGA1	ENSFCAP00000000163	ENSFCAP00000043860	Beta-secretase 1; Belongs to the peptidase A1 family.	Golgi associated, gamma adaptin ear containing, ARF binding protein 1.	0.892
BACE1	IDE	ENSFCAP00000000163	ENSFCAP00000018455	Beta-secretase 1; Belongs to the peptidase A1 family.	Insulin degrading enzyme.	0.885
BACE1	MMEL1	ENSFCAP00000000163	ENSFCAP00000008831	Beta-secretase 1; Belongs to the peptidase A1 family.	Membrane metalloendopeptidase like 1.	0.857
BACE1	NRG1	ENSFCAP00000000163	ENSFCAP00000045227	Beta-secretase 1; Belongs to the peptidase A1 family.	Neuregulin 1.	0.784
BACE1	PSEN1	ENSFCAP00000000163	ENSFCAP00000048165	Beta-secretase 1; Belongs to the peptidase A1 family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.828
BACE1	RTN3	ENSFCAP00000000163	ENSFCAP00000054495	Beta-secretase 1; Belongs to the peptidase A1 family.	Reticulon.	0.960