Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDKL5Cyclin dependent kinase like 5. (978 aa)    
Predicted Functional Partners:
MECP2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
    
 
 0.833
PCDH19
Protocadherin 19.
      
 0.730
FMR1
Fragile X mental retardation 1.
    
 
 0.710
KCNQ2
Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.
   
  
 0.670
FOXG1
Forkhead box G1.
      
 0.659
STXBP1
Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family.
      
 0.594
NTNG1
Netrin G1.
      
 0.575
AP4E1
AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
      
 0.561
MEF2A
Myocyte enhancer factor 2A.
    
 
 0.551
AUTS2
Activator of transcription and developmental regulator AUTS2.
      
 0.547
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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