HBEGF protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HBEGF

Heparin binding EGF like growth factor. (305 aa)

Predicted Functional Partners:

EGFR

0.973

ERBB4

0.966

MMP9

0.925

MMP14

0.918

MMP15

0.915

MMP17

0.914

MMP24

0.914

MMP16

0.914

MMP25

0.914

MMP2

0.912

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB4	ENSFCAP00000041464	ENSFCAP00000042375	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.834
EGFR	HBEGF	ENSFCAP00000041464	ENSFCAP00000001182	Receptor protein-tyrosine kinase.	Heparin binding EGF like growth factor.	0.973
EGFR	MMP14	ENSFCAP00000041464	ENSFCAP00000006156	Receptor protein-tyrosine kinase.	Matrix metallopeptidase 14.	0.434
EGFR	MMP9	ENSFCAP00000041464	ENSFCAP00000012997	Receptor protein-tyrosine kinase.	Matrix metallopeptidase 9.	0.738
ERBB4	EGFR	ENSFCAP00000042375	ENSFCAP00000041464	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.834
ERBB4	HBEGF	ENSFCAP00000042375	ENSFCAP00000001182	Receptor protein-tyrosine kinase.	Heparin binding EGF like growth factor.	0.966
HBEGF	EGFR	ENSFCAP00000001182	ENSFCAP00000041464	Heparin binding EGF like growth factor.	Receptor protein-tyrosine kinase.	0.973
HBEGF	ERBB4	ENSFCAP00000001182	ENSFCAP00000042375	Heparin binding EGF like growth factor.	Receptor protein-tyrosine kinase.	0.966
HBEGF	MMP14	ENSFCAP00000001182	ENSFCAP00000006156	Heparin binding EGF like growth factor.	Matrix metallopeptidase 14.	0.918
HBEGF	MMP15	ENSFCAP00000001182	ENSFCAP00000002480	Heparin binding EGF like growth factor.	Matrix metallopeptidase 15.	0.915
HBEGF	MMP16	ENSFCAP00000001182	ENSFCAP00000017782	Heparin binding EGF like growth factor.	Matrix metallopeptidase 16.	0.914
HBEGF	MMP17	ENSFCAP00000001182	ENSFCAP00000016934	Heparin binding EGF like growth factor.	Matrix metallopeptidase 17.	0.914
HBEGF	MMP2	ENSFCAP00000001182	ENSFCAP00000040098	Heparin binding EGF like growth factor.	Matrix metallopeptidase 2.	0.912
HBEGF	MMP24	ENSFCAP00000001182	ENSFCAP00000017072	Heparin binding EGF like growth factor.	Matrix metallopeptidase 24.	0.914
HBEGF	MMP25	ENSFCAP00000001182	ENSFCAP00000022453	Heparin binding EGF like growth factor.	ZnMc domain-containing protein.	0.914
HBEGF	MMP9	ENSFCAP00000001182	ENSFCAP00000012997	Heparin binding EGF like growth factor.	Matrix metallopeptidase 9.	0.925
MMP14	EGFR	ENSFCAP00000006156	ENSFCAP00000041464	Matrix metallopeptidase 14.	Receptor protein-tyrosine kinase.	0.434
MMP14	HBEGF	ENSFCAP00000006156	ENSFCAP00000001182	Matrix metallopeptidase 14.	Heparin binding EGF like growth factor.	0.918
MMP14	MMP15	ENSFCAP00000006156	ENSFCAP00000002480	Matrix metallopeptidase 14.	Matrix metallopeptidase 15.	0.559
MMP14	MMP16	ENSFCAP00000006156	ENSFCAP00000017782	Matrix metallopeptidase 14.	Matrix metallopeptidase 16.	0.561