Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTH2Parathyroid hormone 2. (99 aa)    
Predicted Functional Partners:
PTH2R
Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.992
PTH1R
Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.980
PTH
Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
     
 0.958
TCAIM
T cell activation inhibitor, mitochondrial.
      
 0.761
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
      
 0.690
PTHLH
Parathyroid hormone like hormone.
     
 0.524
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
      
 0.480
TOR2A
Torsin.
      
 0.434
POLD1
DNA polymerase.
      
 0.431
SCTR
Secretin receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.428
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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