Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)    
Predicted Functional Partners:
CREB1
cAMP responsive element binding protein 1.
    
 0.970
CALML6
Calmodulin like 6.
    
 0.961
CALML4
Calmodulin like 4.
    
 0.961
ENSFCAP00000043586
Uncharacterized protein.
    
 0.947
ATF1
Activating transcription factor 1.
    
 0.946
CREBBP
CREB binding protein.
    
 0.935
CAMKK2
Calcium/calmodulin dependent protein kinase kinase 2.
  
 
0.933
ADCY8
Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
    
 0.924
CAMKK1
Calcium/calmodulin dependent protein kinase kinase 1.
    
 0.922
HDAC5
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
 0.921
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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