APP protein (Felis catus) - STRING interaction network

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APP

Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] (935 aa)

Predicted Functional Partners:

HPX

0.997

BACE1

0.995

PSEN1

0.995

SORL1

0.991

NAE1

0.980

APLP2

0.974

APBB2

0.974

CLU

0.973

MAPT

0.968

PSEN2

0.964

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB2	APLP2	ENSFCAP00000029145	ENSFCAP00000008808	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor like protein 2.	0.932
APBB2	APP	ENSFCAP00000029145	ENSFCAP00000001445	Amyloid beta precursor protein binding family B member 2.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.974
APBB2	BACE1	ENSFCAP00000029145	ENSFCAP00000000163	Amyloid beta precursor protein binding family B member 2.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.571
APBB2	CLU	ENSFCAP00000029145	ENSFCAP00000013377	Amyloid beta precursor protein binding family B member 2.	Clusterin; Belongs to the clusterin family.	0.433
APBB2	HPX	ENSFCAP00000029145	ENSFCAP00000059101	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.879
APBB2	PSEN1	ENSFCAP00000029145	ENSFCAP00000048165	Amyloid beta precursor protein binding family B member 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.448
APLP2	APBB2	ENSFCAP00000008808	ENSFCAP00000029145	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 2.	0.932
APLP2	APP	ENSFCAP00000008808	ENSFCAP00000001445	Amyloid beta precursor like protein 2.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.974
APLP2	BACE1	ENSFCAP00000008808	ENSFCAP00000000163	Amyloid beta precursor like protein 2.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.841
APLP2	CLU	ENSFCAP00000008808	ENSFCAP00000013377	Amyloid beta precursor like protein 2.	Clusterin; Belongs to the clusterin family.	0.734
APLP2	HPX	ENSFCAP00000008808	ENSFCAP00000059101	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 1.	0.944
APLP2	MAPT	ENSFCAP00000008808	ENSFCAP00000041907	Amyloid beta precursor like protein 2.	Microtubule-associated protein.	0.629
APLP2	NAE1	ENSFCAP00000008808	ENSFCAP00000011841	Amyloid beta precursor like protein 2.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.793
APLP2	PSEN1	ENSFCAP00000008808	ENSFCAP00000048165	Amyloid beta precursor like protein 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.681
APLP2	PSEN2	ENSFCAP00000008808	ENSFCAP00000044391	Amyloid beta precursor like protein 2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.681
APLP2	SORL1	ENSFCAP00000008808	ENSFCAP00000012262	Amyloid beta precursor like protein 2.	Sortilin related receptor 1.	0.817
APP	APBB2	ENSFCAP00000001445	ENSFCAP00000029145	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Amyloid beta precursor protein binding family B member 2.	0.974
APP	APLP2	ENSFCAP00000001445	ENSFCAP00000008808	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Amyloid beta precursor like protein 2.	0.974
APP	BACE1	ENSFCAP00000001445	ENSFCAP00000000163	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Beta-secretase 1; Belongs to the peptidase A1 family.	0.995
APP	CLU	ENSFCAP00000001445	ENSFCAP00000013377	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Clusterin; Belongs to the clusterin family.	0.973

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