Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
G2E3G2/M-phase specific E3 ubiquitin protein ligase. (706 aa)    
Predicted Functional Partners:
GAS2L3
Growth arrest specific 2 like 3.
   
  
 0.744
SCFD1
Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family.
 
    
 0.741
DLGAP5
DLG associated protein 5.
   
  
 0.688
WDR6
WD repeat domain 6.
    
   0.649
CKAP5
Cytoskeleton associated protein 5.
   
  
 0.643
CBX5
Chromobox 5.
    
 0.643
CDCA8
Cell division cycle associated 8.
   
 0.631
NCAPD2
Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
      
 0.626
KIF23
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.614
SMC4
Structural maintenance of chromosomes protein.
   
 
 0.610
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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